THE ANTI-INFLAMMATORY POTENTIAL OF CARICA PAPAYA LINN. LEAVES: AN IN VIVO STUDY
Main Article Content
Keywords
Inflammatory Diseases, Carica papaya, Anti-Inflammatory, Plant Extract, Therapeutic Dose, Oral Drug, Carrageenan Paw Edema, Pharmacological Activities, Rats
Abstract
This study explores the anti-inflammatory activities of Carica papaya Linn. leaves. The research involved in vivo experimentation using rats as the animal model. The anti-inflammatory effect of papaya leaves was demonstrated through carrageenan-induced paw edema, a widely recognized method. Four different oral doses (100 mg/kg, 200 mg/kg, 300 mg/kg, and 400 mg/kg) were tested. Comparative analysis was conducted among the experimental, control, and reference groups. Statistical analysis using ANOVA and t-test (p<0.05) confirmed the anti-inflammatory properties of the leaves. All doses exhibited significant anti-inflammatory effects, with 300 mg/kg and 400 mg/kg doses showing particularly marked effects, displaying percent inhibition of paw edema comparable to or exceeding that of the reference drug, indomethacin. This method revealed that the anti-inflammatory activity of aqueous Carica papaya leaf extract is dose-dependent, with effects increasing over time. The results support the potential of aqueous papaya leaf extract for treating acute inflammatory diseases.
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Tooba Ishaque Shaikh
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Syeda Afroz
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Tahira Mujtaba
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Hina Tabassum
Department of Pharmacology, Dow Institute of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan.
Aisha Hasan
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Aniqa Naz
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Ujala Sodhar
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Wardah Jawaid
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Wasima Anjum
Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan
Azmat Ara
Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan