ANTIDIABETIC, HYPOLIPIDEMIC AND PHYTOCHEMICAL ANALYSIS OF PEGANUM HARMALA ETHANOL EXTRACT IN ANIMAL MODEL

Ameer Muhammad; Sabira Sultana; Abid Rashid; Sultan Ayaz; Muhammad Akram

doi:10.53555/jptcp.v31i1.4165

Ameer Muhammad
Sabira Sultana
Abid Rashid
Sultan Ayaz
Muhammad Akram

Keywords

Peganum harmala, ethanol extract, antioxidant, diabetes mellitus, medicinal plants, antihyperlipidemic

Abstract

Aims: The study was designed to determine Peganum harmala seeds effects on Streptozotocin induced Diabetes, Obesity and triglycerides levels in Swiss Albino Mice.

Material and Methods: The antidiabetic activity was assessed on three different models normoglycemic, oral glucose tolerated mice and Streptozotocin induced diabetic mice. The antioxidant analysis was done by ABTS, FRAP, DPPH and phytochemical estimation was carried out by HPLC, TPC (Total phenolic contents), TFC (Total flavonoids contents).

Results: The ethanol extract of Peganum harmala seed extract (EEPHS) showed significant (p>0.001) hypoglycemic activity in all the three models. Similarly, significant p>0.05 concentration dependent antioxidant potential was seen by all three methods. The extract showed considerable range of TPC and TFC. The HPLC analysis showed the presence of potentially active compound such as quercetin, gallic acid, Sinapic acid vanillic acid, Ferulic acid, chlorogenic acid, Syringic acid, Cinnamic acid.

Conclusion: Peganum harmala seeds extract showed Significant anti-hyperglycemic activity and anti-hyperlipidemic activity.

Abstract 129 | PDF Downloads 75

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Published

Jan 30, 2024

DOI https://doi.org/10.53555/jptcp.v31i1.4165

How to Cite

Ameer Muhammad, Sabira Sultana, Abid Rashid, Sultan Ayaz, & Muhammad Akram. (2024). ANTIDIABETIC, HYPOLIPIDEMIC AND PHYTOCHEMICAL ANALYSIS OF PEGANUM HARMALA ETHANOL EXTRACT IN ANIMAL MODEL. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 2068–2080. https://doi.org/10.53555/jptcp.v31i1.4165

Issue

Vol. 31 No. 1 (2024): JPTCP

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Articles

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