SEVERITY OF NEUTROPENIA IN PATIENTS WITH NON-HODGKIN B-CELL LYMPHOMAS ON R-CHOP CHEMOTHERAPY REGIMEN

Main Article Content

Assam Ahmad
Bilal Ahmad
Syeda Sama Bilal
Jahan Sardar
Sohail Ahmad
Rahimullah Khattak

Keywords

Non-Hodgkin's lymphomas, Chemotherapy, Neutropenia

Abstract

Background: Neutropenia is a condition in which the neutrophil concentration in the blood is unusually low. A reduction in the non-marginal pool's circulating neutrophils is known as neutrtropenia. Drug-induced neutropenia affects one person in a million per year, according to the CDC. Non- Hodgkin's lymphoma (NHL) is the category of lymphoproliferative diseases with various clinical and histological presentations.


Objective: To assess the frequency of neutropenia and its severity in patients diagnosed with B-cell Non-Hodgkin's lymphomas on R-CHOP chemotherapy regimen


Material & Methods


Study Design: Cross - sectional study


Study place: Department of Oncology, Combined Military Hospital, Rawalpindi


Duration: 06 months i.e. from 20-5-2019 to 20-11-2019


Data collection: After meeting the inclusion criteria 90 patients were enrolled in this study. Then patients were planned for the first session of RCHOP chemotherapy. The dose of chemotherapy was estimated by using body surface area as per standard guidelines given in operational definition. 48 hours after completion of first cycle of RCHOP therapy, blood CP was performed from the hospital laboratory and neutrophil count along with hemoglobin level was observed. Grade of neutropenia was assessed as per operational definitions.


Results: The mean age of patients was 43.43±11.73 years, 53 (58.89%) were male. Zero grade of anemia was noted in 38 (42.2%) patients. Out of 90 patients, neutropenia was noted in 45 (50%) patients.


Conclusion: Approximately half of the total patients developed neutropenia who were diagnosed with B-cell NHL on R-CHOP chemotherapy regimen

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