COMPARISON OF THE EFFICACY OF COMBINATION OF TAM FORMULA VERSUS KLIGMAN FORMULA FOR MELASMA AT TERTIARY CARE HOSPITAL, KARACHI

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Khadija Asadullah
Rabia Ghafoor
Parisa Sanawar
Nazia Jabeen
Faiza Inam Siddiqui
Misbah Qadir

Keywords

Melasma, kligman formula, TAM formula, Melasma Area, Severity Index

Abstract

Objective: Comparison of the efficacy of combination of TAM formula versus Kligman formula for melasma at Tertiary Care Hospital, Karachi.


Study design: Randomized controlled trail.


Place and duration of study: This study was conducted at Department of Dermatology, JPMC, Karachi from 1st January, 2022 till 31st January, 2023.


Material and methods: Data was prospectively collected from patients after taking consent. The sample size for the study was 122 patients, 61 in each group were included. Medical history, complete examination of skin and Melasma Area and Severity Index (MASI) Scores calculated before and after treatment to evaluate the change from baseline. Quantitative data was presented as simple descriptive statistics giving mean and standard deviation and qualitative variables was presented as frequency and percentages.


Results: The mean ages were 35.95 ± 7.17 years and 38.85 ± 7.80 years in Groups T and K, respectively. Both groups had a predominantly female distribution (98.4% in Group T, 88.5% in Group K). In terms of efficacy, TAM group demonstrated a higher response (98.4%) compared to Kligman group (90.2%). Over the eight weeks, group T and group K showed notable decrease in their mean MASI score, but group T has more better results.


Conclusion: In conclusion, the comparison between the TAM and Kligman formulas suggests that both have good efficacy and results in treating melasma patients, with TAM demonstrating more prominent decrease in mean MASI scores in a smaller time period and good patient satisfaction rates.  However, further studies are needed to evaluate the long term results and side effects of this new formula.

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