TREATMENT OUTCOME OF AUTOLOGOUS PLATELET-RICH PLASMA VERSUS CONVENTIONAL THERAPY AMONG PATIENTS WITH CHRONIC VENOUS LEG ULCERS
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Keywords
Outcome, Autologous platelet-rich plasma (PRP), Conventional Therapy, Chronic Venous Leg Ulcers
Abstract
Objective: To compare the outcome of treatment with autologous platelet-rich plasma (PRP) versus conventional therapy for patients with chronic venous leg ulcers.
Methods: This randomized controlled trial was conducted at the department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi from 1st September 2022 to 25th May 2023. Patients aged 30-80 years of either gender having chronic venous leg ulcer were enrolled. Patients were randomly allocated to Autologous PRP and conventional therapy group. PRP was applied after proper surgical debridement and was dressed with a non-absorbent dressing once weekly for 6 weeks. Conservative therapy was performed by compression using graduated elastic stockings below the knee and dressing using Saline and Vaseline gauze weekly for 6 weeks. Outcome was assessed in terms of complete healing, length of ulcer, and width of ulcer at 6 weeks.
Results: Of 96 patients, the mean age was 59.17 ±7.01 years. There were 53 (55.2%) females and 43 (44.8%) males. A significantly lower mean length of ulcer at 6 weeks was observed in PRP than conventional therapy patients, i.e., 2.11 ±0.88 vs. 2.97 ±0.84 (p-value <0.001). Moreover, a significant mean difference of width of ulcer at 6 weeks was observed in PRP than conventional therapy patients, i.e., i.e., 1.36 ±0.42 vs. 1.54 ±0.39 (p-value 0.037). Moreover, a significantly higher frequency of complete healing was observed in PRP than conventional therapy, i.e., 26 (54.2%) and 7 (14.6%) respectively (p-value <0.001).
Conclusion: A better outcome of PRP was observed compared to conventional therapy in patients with chronic venous leg ulcers.
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Faiza Inam
Postgraduate Trainee Dermatology, Jinnah Post Graduate Medical Center (JPMC), Karachi - Pakistan
Rabia Ghafoor
Associate Professor Dermatology, Jinnah Post Graduate Medical Center (JPMC), Karachi – Pakistan
Parisa Sanawar
Postgraduate Trainee Dermatology, Jinnah Post Graduate Medical Center (JPMC), Karachi - Pakistan
Khadija Asadullah
Postgraduate Trainee Dermatology, Jinnah Post Graduate Medical Center (JPMC), Karachi - Pakistan
Nazia Jabeen
Postgraduate Trainee Dermatology, Jinnah Post Graduate Medical Center (JPMC), Karachi - Pakistan
Ammar Farooq
Divisional Headquarters Teaching Hospital, Mirpur - AJK