FREQUENCY OF FIBROADENOMA IN PATIENTS PRESENTING WITH PALPABLE BREAST LUMP

Main Article Content

Sughran Khatoon
Pooja Kumari
Zoya Mehran
Ibrahim Asghar
Aisha Shaikh
Saira Fatima

Keywords

Fibroadenoma, Breast Lumps, Ultrasound, Cancer, Breast Disorders

Abstract

Background: Breast cancer is a global health concern, with rising incidence in developing countries due to factors like increased life expectancy and Western lifestyle adoption, necessitating effective differentiation of benign and malignant breast lumps. Fibroadenoma, a common benign lesion, often affecting women aged 20 to 35, underscores the importance of early detection and management in breast health.


Objective: The main objective of study was to determine the frequency of fibroadenoma in patients presenting with breast lumps.


Methodology: The study, employing a descriptive cross-sectional design, transpired at the Outpatient Department of General Surgery, Shaheed Mohtarma Benazir Bhutto Medical University (SMBBMU) in Larkana, Pakistan, over a six-month period from October 25, 2019, to April 24, 2020, following approval of the synopsis. Rigorous observations and examinations were conducted, encompassing a detailed history of signs and symptoms. During surgical procedures, specimens were collected and sent to the laboratory for assessing the primary variable, fibroadenoma. Data collected were meticulously entered into the provided proforma, electronically utilized for research purposes.


Results: In this study, 151 patients were examined to assess fibroadenoma in those presenting with breast lumps. The mean age was 24.2±5.1 years, with a 95% confidence interval of 23.37 to 25.02. The mean weight was 68.5±8.4 kg (95% CI: 67.14 to 69.85), the mean height was 1.59±0.87 meters (95% CI: 1.45 to 1.72), and the mean body mass index was 26.8±5.7 kg/m2 (95% CI: 25.88 to 27.71). Surgical site distribution revealed 43.7% (n=66) on the right side and 56.3% (n=85) on the left side. Fibroadenoma was documented in 35.1% (n=53) of patients.


Conclusion: In conclusion, fibroadenoma emerged as a prevalent benign breast disorder in women with breast lumps. This highlights the need for proactive measures, such as the implementation of breast screening programs, to enhance early detection and management.

Abstract 105 | pdf Downloads 46

References

1. Schiebinger LL. Nature's body: Gender in the making of modern science. Rutgers University Press; 2004.
2. Sabel MS. Essentials of Breast Surgery: A Volume in the Surgical Foundations Series E-Book. Elsevier Health Sciences; 2009 Apr 23.
3. Khokher S, Qureshi MU, Riaz M, Akhtar N, Saleem A. Clinicopathologic profile of breast cancer patients in Pakistan: ten years data of a local cancer hospital. Asian Pacific Journal of Cancer Prevention. 2012;13(2):693-8.
4. Roshandel G, Sadjadi A, Aarabi M, Keshtkar A, Sedaghat SM, Nouraie SM, Semnani S, Malekzadeh R. Cancer incidence in Golestan Province: report of an ongoing population-based cancer registry in Iran between 2004 and 2008.
5. Agarwal G, Pradeep PV, Aggarwal V, Yip CH, Cheung PS. Spectrum of breast cancer in Asian women. World journal of surgery. 2007 May;31(5):1031-40.
6. Ricks D. Breast Cancer Basics and Beyond: treatments, resources, self-help, good news, updates. Hunter House; 2005.
7. Manoranjan UD, Sangolli MS, Gogate AS. Role of ultrasonography in diagnosis of palpable breast lumps: one year cross sectional study. Recent Research in Science and Technology. 2010 Oct 19;2(8).
8. Cant PJ, Madden MV, Coleman MG, Dent DM. Non-operative management of breast masses diagnosed as fibroadenoma. Journal of British Surgery. 1995 Jun;82(6):792-4.
9. Eleftheriades A, Tsarna E, Toutoudaki K, Paschalidou E, Christopoulos N, Georgopoulos I, Mitropoulou G, Christopoulos P. Giant juvenile fibroadenoma: Case report and review of the literature. Journal of Clinical Medicine. 2023 Feb 26;12(5):1855.
10. Chinnaiah E, Nagireddy TV. A clinical study of benign breast diseases. Int J Surg Sci. 2020;4(1):287-90.
11. Li J, Humphreys K, Ho PJ, Eriksson M, Darai-Ramqvist E, Lindström LS, Hall P, Czene K. Family history, reproductive, and lifestyle risk factors for fibroadenoma and breast cancer. JNCI Cancer Spectrum. 2018 Nov;2(3): pky051.
12. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. Histopathology of fibroadenoma of the breast. American journal of clinical pathology. 2001 May 1;115(5):736-42.
13. Kumar N, Prasad J. Epidemiology of benign breast lumps, is it changing: a prospective study. International Surgery Journal. 2019 Jan 28;6(2):465-9.
14. Prajapati CL, Patel UA, Patel J. Breast lumps in a teaching hospital: A 5year study. National Journal of Medical Research. 2014 Mar 31;4(01):65-7.
15. Koo MM, Swann R, McPhail S, Abel GA, Elliss-Brookes L, Rubin GP, Lyratzopoulos G. Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study. The Lancet Oncology. 2020 Jan 1;21(1):73-9.
16. Saeed S, Asim M, Sohail MM. Fears and barriers: problems in breast cancer diagnosis and treatment in Pakistan. BMC women's health. 2021 Dec;21(1):1-0.
17. Ahmed I, Nazir R, Chaudhary MY, Kundi S. Triple assessment of breast lump. Journal of the College of Physicians and Surgeons--pakistan: JCPSP. 2007 Sep 1;17(9):535-8.
18. Chandran S, Jesudoss I. Benign Breast Disorders-An overview. IOSR J Nurs Heal Sci. 2020; 9:22-6.
19. LE H. Aberations of normal development and involution (ANDI): A new perspective on pathogenesis and nomenclature of benign breast disorders. Lancet. 1987; 5:1316-9.
20. Hughes LE, Mansel RE, Webster DJ. Benign disorders and diseases of the breast: concepts and clinical management. (No Title). 1989.
21. Fornage BD, Lorigan JG, Andry E. Fibroadenoma of the breast: sonographic appearance. Radiology. 1989 Sep;172(3):671-5.
22. JACKSON VP, ROTHSCHILD PA, KREIPKE DL, MAIL JT, HOLDEN RW. The spectrum of sonographic findings of fibroadenoma of the breast. Investigative radiology. 1986 Jan 1;21(1):34-40.
23. Isaac U, Memon F, Zohra N. Frequency of breast diseases at a Tertiary Hospital of Karachi. JLUMHS. 2005 Jan;4(1):6-9.
24. Khanam A, Khan AZ, Nazir A, Saleem M, Bhutta AR, Abid KJ. Social aspects of patients with carcinoma breast presented to Sir Ganga Ram Hospital Lahore. Annals of King Edward Medical University. 2004;10(2).
25. Cheung KL, Lam TP. Approach to a lump in the breast: a regional perspective. Asian journal of surgery. 2005 Jan 1;28(1):65-70.
26. Moran MS, Yang Q, Haffty BG. The Yale University experience of early‐stage invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) treated with breast conservation treatment (BCT): Analysis of clinical‐pathologic features, long‐term outcomes, and molecular expression of COX‐2, Bcl‐2, and p53 as a function of histology. The Breast Journal. 2009 Nov;15(6):571-8.
27. Khemka A, Chakrabarti N, Shah S, Patel V. Palpable breast lumps: Fine-needle aspiration cytology versus histopathology: A correlation of diagnostic accuracy. Internet J Surg. 2009 Dec 1;18(1).
28. Roche NA, Ray SA, Layer GT. Immediate cytodiagnosis and imaging in the clinical management of discrete benign breast lesions. Annals of the Royal College of Surgeons of England. 1997 Jul;79(4):268.
29. Hartmann LC, MAYO CLINIC ROCHESTER MN. Benign Breast Disease: Toward Molecular Prediction of Breast Cancer Risk.
30. Talpur KA, Laghari AA, Malik AM, Memon A. Clinico-pathological profile of patients with breast diseases at university hospital, Jamshoro. Jlumhs. 2006 May;5(2):71-5.
31. Rashid R, Haq SM, Khan K, Jamal S, Khaliq T, Shah A. Benign breast disorders, a clinicopathological study. Ann Pak Inst Med Sci. 2005;1(4):187-90.
32. Jamal AA. Pattern of breast diseases in a teaching hospital in Jeddah, Saudi Arabia. Saudi medical journal. 2001 Feb 1;22(2):110-3.
33. Kumar R. A clinicopathologic study of breast lumps in Bhairahwa, Nepal. Asian Pac J Cancer Prev. 2010 Jan 1;11(4):855-.
34. Ali K, Abbas MH, Aslam S, Aslam M, Abid KJ, Khan AZ. Frequency of benign breast diseases in female patients presenting with breast lumps-a study at Sir Ganga Ram Hospital, Lahore. Annals of King Edward Medical University. 2005;11(4).
35. Chaudhary IA, Qureshi SK, Rasul S. Incidence of malignancy in females presenting with breast lumps in OPD: a study of 277 cases. Age (Years). 2003 Oct;40(30):20.
36. Wirtzfeld LA, Nam K, Labyed Y, Ghoshal G, Haak A, Sen-Gupta E, He Z, Hirtz NR, Miller RJ, Sarwate S, Simpson DG. Techniques and evaluation from a cross-platform imaging comparison of quantitative ultrasound parameters in an in vivo rodent fibroadenoma model. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 2013 Jul 4;60(7):1386-400.
37. Limite G, Esposito E, Sollazzo V, Ciancia G, Di Micco R, De Rosa D, Forestieri P. Lobular intraepithelial neoplasia arising within breast fibroadenoma. BMC research Notes. 2013 Dec;6:1-4.
38. Zaĭtsev AN, Vesnin AG, Semiglazov VF, Orlov AA, Chernomordikova MF, Chebykin IA, Brezhneva TV. Ultrasound differentiation of fibroadenoma and diagnosis of minimal carcinoma of the breast. Voprosy Onkologii. 1998 Jan 1;44(2):198-202.
39. Asirvatham JR, Shah A, Carreon CK, Bhuiya TA, Kahn LB, Kostroff K, Morgenstern NJ. Ossifying fibromyxoid tumor of the breast mimicking fibroadenoma: a case report and differential diagnoses. Archives of Pathology and Laboratory Medicine. 2014 Aug 1;138(8):1098-100.
40. Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A. Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy. La radiologia medica. 2011 Sep 1;116(6):905-18.