FORMULATION AND EVALUATION OF LIPOSOMAL GEL WITH DAPSONE

Main Article Content

pooja kumari
Mrs Priyanka Maurya
Dr.jai Narayan Mishra

Keywords

Liposome, Dapsone, topical administration, Franz diffusion cell, and in-vitro release

Abstract

The current investigation employed a method to assess the effectiveness of liposomes as a new type of lipid for delivering dapsone through the skin. To optimize the liposomes, adjustments were made to the concentrations of ethanol phospholipids and cholesterol. Ultimately, liposomes composed of soy lecithin, ethanol, and cholesterol were found to be the most optimal. The results revealed that the F7 formulation yielded spherical, unilamellar vesicles with a smooth surface, demonstrating superior outcomes. The topical administration of dapsone may offer an alternative method of acne valgeris as well as novel therapeutic uses for a known medication. Dapsone is challenging to include into standard formulations due to its physicochemical characteristics. The goal of the current study was to create a stable liposomal containing dapsone that could be modified for topical application

Abstract 259 | pdf Downloads 130

References

1. A.D.BanghamandR.W.Horne(1964),Negativestainingofphospholipidsandtheirstructuremodificationbysurfaceactiveagentsasobservedintheelectronmicroscope,J.Mol.Biol.
2. A.Sharma,U.S.Sharma,(1997),Liposomesindrugdelivery:progressandlimitations,Internationaljournalofpharmaceutics154(1997)123-140.
3. Available from www.pharmainfo.net/reviews/topical-drug- delivery-system-review. Shailesh, Topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes, 2008, 1-13.
4. Bangham A.D., editor. The Liposome Letters. Academic Press; 1983.
5. Barner A. Review of clinical trials and benefit/risk ratio of Dapsone. Scandinavian J of Rheumatology. 1996; 25(102):29-37.
6. Barry BW, Novel mechanism and devices to enable successful transdermal drug delivery, Eur J Pharm Sci, 2001; 14: 101-14.
7. Barry BW. Is transdermal drug delivery research still important today, Drug Discover Today. 2001; 6(19):967-71.
8. Biju SS, Sushama T, Mishra PR, Khar RK. Vesicular systems: An overview, Ind. J. Pharma Sci. 2006; 68(2):141-53.
9. Cevc G, Blume G, Schatzlein A, Gebauer D, Paul A. The skin pathway for systemic treatment patches and lipid based agent carriers, Advanced Drug Delivery Reviews. 1996; 18:349-78.
10. CJ Beukelman, MJ Hoekstra, K Reimer, S Mueller. Anti- inflammatory properties of a liposomal hydrogel with povidone- iodine for wound healing in vitro burns, International Journal of Pharmaceutics. 2008; 34(6):845-55.
11. D.A.White,C.BAnsell,J.N.HawthorneR.M.CDawson,Eds.1973,ThephospholipidscompositionofmammaliantissueIn:FormandFunctionofphospholipids.
12. D.D. Lasic, (1992), Liposomes, Am.Sci.80,20–31.
13. Dinesh D, Amit AR, Maria S, Awaroop RL, Mohd Hassan GD. Drug vehicle based approaches of penetration enhancement, International Journal of Pharmaceutical Sciences. 2009; 1(1):24-45.
14. Dusane Abhijit Ratilal, Gaikwad Priti D, Bankar Vidyadhar H, Pawar Sunil P. a Review on: Sustained Released Technology, IJRAP. 2011; 2(6):1701-08.
15. Dwijaya, A., & Atmaja, M. H. S. (2022). Clinical and imaging findings of klippel-trenaunay syndrome: A case report. International Journal of Health & Medical Sciences, 5(1), 145-149. https://doi.org/10.21744/ijhms.v5n1.1860
16. Ehrlich, P. The relations existing between chemical constitution, distribution and pharmacological action. In Ehrlich, P. (Ed.), Collected Studies on Immunity, Vol. 2, Wiley, New York, 1906, pp. 404 443.
17. Elsayed MM, Ossama YA, Naggar VF, Khalafallah NM. Deformable liposomes and ethosomes: Mechanism of enhanced skin delivery, International Journal of Pharmaceutics. 2006; 322:60-66.
18. Evans,D.F.,Wennerström,H.Thecolloidaldomain:wherephysics,chemistry,biologyandtechnologymeet,VCHPublishersInc.,1994.
19. W Andreas, Karola-Uhl. Liposome technology for industrial purposes. Journal of Drug Delivery; 2011:1-9.
20. M Mansoori, S Agrawal, S Jawade, M. I. Khan. Review on Liposome. International Journal of Advanced Research Pharmaceutical and Bio Sciences, 2012; 2 (4):453- 464.
21. V.N.L Sirisha, I. BhavaniHarika, B. Sruthi, Namrata, P. Kirankumar, Y. Kiran Kumar Rao, K. Pranavi, S. Sindhura, N. Vamsi Krishna, O. UmaMaheshwaraRao. Liposomes – the potential drug carriers. IOSR Journal of Pharmacy, 2012; 2(5): 26-38.
22. Abdus Samad, Y. Sultana and M. Aqil. Liposomal drug delivery systems: An update review. Current drug delivery, 2007; 4(4): 297-305.
23. R. Lipowsky and E. Sackmann. Applications of Liposomes, Handbook of Biological Physics. 1995; 1: 491-519
24. S.P. Vyas and R.K. Khar. Targeted and controlled drug delivery novel carrier systems. 2011: 173-248.
25. David B. Troy and Paul Beringer. Remington: The Science and Practice of Pharmacy. 21st edition; 2006: 766-767.
26. Maik Hadorn, Eva Boenzli, Peter Eggenberger Hotz and Martin M. Hanczyc. Hierarchical unilamellar vesicles of controlled compositional heterogeneity. Plos one 2012; 7(11):1-7.
27. Olga Popovska, Jana Simonovska, Zoran Kavrakovski and Vesna Rafajlovska. An Overview: Methods for Preparation and Characterization of Liposomes as Drug Delivery Systems. International Journal of Pharmaceutical and Psychopharmacological Research, 2013; 3 (3): 182-189.
28. Kant shashi, Kumar Satinder and Prashar bharat. A complete review on: Liposomes. International research journal of pharmacy, 2012; 3(7):10-16.
29. Rutuja Ravindra Deshmukh, Snehal Vijay Gawale, Megha Kailas Bhagwat, Priyanka, Arvind Ahire and Nikita Diliprao Derle. A review on: liposomes. World journal of pharmacy and pharmaceutical sciences, 2016; 5(3):506-517.
30. Manivannan Rangasamy and Kugalur Ganesan Parthiban. Recent advances in novel drug delivery system.
31. Dina Fathalla, Ghareb M. Soliman and Ehab A. Fouad. Development and in vitro/in vivo evaluation of liposomal gels for the sustained ocular delivery of latanoprost. Journal of Clinical & Experimental Ophthalmology. 2015; 6(1): 1-9.
32. S. Rathod and S. G. Deshpande. Design and evaluation of liposomal formulation of pilocarpine nitrate. Indian Journal of Pharmaceutical Science, 2009; 72(2): 155-160.
33. Thi lan nguyen, Thi hiep nguyen and Dai hai nguyen. Development and in vitro evaluation of liposomes using soy lecithin to encapsulated paclitaxel. International journal of Biomaterials, 2017;
34. Ajay Kumar, Shital Badde, Ravindra Kamble and Varsha B. Pokharkar, Development and characterization of liposomal drug delivery system for Nimesulide. International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2(4): 87-89