EVALUATION OF THE ACTIVITY OF ARACHIS HYPOGAEA ON COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN RATS

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Boya Minigi Jyothi
Dr. Md sultan Ali Basha
Sirivella Pravallika
Mangali Jaya Prakash
D. Riyazunnisa
Shaik Mahaboob Bee

Keywords

Arachis hypogaea, arthritis, anti-inflammatory, histopathological examination, hematological parameters, biochemical parameters

Abstract

Arthritis is a prevalent inflammatory condition that poses a significant burden on individuals and healthcare systems worldwide. This study aimed to evaluate the anti-arthritis activity of the ethanolic extract of Arachis hypogaea in a rat model of arthritis induced by Complete Freund's Adjuvant (CFA) injection. The extract exhibited significant reductions in paw edema volume compared to the control group, indicating its potential as an anti-inflammatory agent. Histopathological examination revealed a decrease in inflammatory cell aggregation and minimal tissue injury in the extract-treated groups, suggesting its ability to attenuate inflammation. Hematological parameters, including hemoglobin levels, RBC count, and WBC count, showed improvements in the extract-treated groups, indicating potential restoration of altered inflammatory markers. Biochemical analysis demonstrated a decrease in SGPT, SGOT, and alkaline phosphatase levels after treatment with the extract, indicating possible modulation of liver function. These findings support the potential of Arachis hypogaea as a natural anti-inflammatory agent for arthritis management. Further research is needed to elucidate its underlying mechanisms of action and isolate active compounds responsible for its therapeutic effects.

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