THERAPEUTIC EVALUATION OF GENTIANA OLIVIERI GRISEB AND FICUS RACEMOSA LINN FOR DIABETES TREATMENT: AN ALLOXAN-INDUCED DIABETIC ANIMAL MODEL STUDY

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Sirivella Pravallika
Dr. Md sultan Ali Basha
Boya Minigi Jyothi
Mangali Jaya Prakash
D. Riyazunnisa
Shaik Mahaboob Bee

Keywords

Gentiana olivieri Griseb, Ficus racemosa Linn, alloxan-induced diabetic animal model, hypoglycemic activity

Abstract

Diabetes mellitus is a prevalent metabolic disorder characterized by elevated blood glucose levels and impaired insulin function. The search for effective natural treatments has led to the investigation of botanical extracts, including Gentiana olivieri Griseb and Ficus racemosa Linn, for their therapeutic potential in diabetes management. In this study, we evaluated the antidiabetic effects of these extracts using an alloxan-induced diabetic animal model. Animals were divided into five treatment groups: normal control, diabetic control, standard drug (glibenclamide), Gentiana olivieri Griseb extract (M.G.O), and Ficus racemosa Linn extract (M.F.R). Daily administration of the respective interventions was carried out for a predetermined duration. Phytochemical screening was conducted to identify the bioactive compounds present in the extracts. Fasting blood glucose (FBG) and postprandial blood glucose (PPG) levels were measured as indicators of glycemic control. Histopathological analysis was performed to assess tissue morphology and inflammation. Phytochemical screening revealed the presence of bioactive compounds in the methanolic extracts of Gentiana olivieri Griseb and Ficus racemosa Linn. Treatment with these extracts resulted in significant reductions in FBG levels compared to the diabetic control group. Furthermore, the extracts exhibited promising effects in lowering PPG levels. Histopathological examination demonstrated improvements in tissue morphology and reduced inflammation in the treated groups. The findings of this study suggest that Gentiana olivieri Griseb and Ficus racemosa Linn extracts possess therapeutic potential for the management of diabetes. These botanical extracts showed significant hypoglycemic effects and ameliorated tissue inflammation. The presence of bioactive compounds in the extracts may contribute to their antidiabetic properties

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