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Shaik Mohemmed Zeeshan Ali
Dr. MD Sultan Ali Basha
Preethi Kuruva
Gotla Anand
D. Riyazunnisa
Shaik Mahaboob Bee


Urolithiasis, Ethanolic Extract, Mangifera indica, Anti-lithiatic, Hyperoxaluria, Calcium Oxalate, Natural Remedy


Urolithiasis, the formation of kidney stones, represents a prevalent and distressing urological disorder. In this study, the potential antiurolithiatic activity of ethanolic extract of Mangifera indica leaves (EEMI) was investigated using in vitro assays and an ethylene glycol-induced urolithiatic rat model. EEMI exhibited significant inhibitory effects on calcium oxalate crystal nucleation and aggregation, crucial steps in stone formation. Moreover, EEMI demonstrated a low toxicity profile in acute toxicity assessments, affirming its safety. In an ethylene glycol-induced rat model, EEMI effectively restored serum and urinary parameters, indicating its ability to preserve kidney function and mitigate hyperoxaluria. These findings highlight the promise of EEMI as a potential natural remedy for kidney stone prevention and management, warranting further research and clinical studies.

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