PHARMACOLOGICAL EVALUATION OF THE ETHANOLIC EXTRACT OF MANGIFERA INDICA LEAVES AGAINST ETHYLENE GLYCOL-INDUCED UROLITHIASIS IN WISTAR ALBINO RATS.
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Keywords
Urolithiasis, Ethanolic Extract, Mangifera indica, Anti-lithiatic, Hyperoxaluria, Calcium Oxalate, Natural Remedy
Abstract
Urolithiasis, the formation of kidney stones, represents a prevalent and distressing urological disorder. In this study, the potential antiurolithiatic activity of ethanolic extract of Mangifera indica leaves (EEMI) was investigated using in vitro assays and an ethylene glycol-induced urolithiatic rat model. EEMI exhibited significant inhibitory effects on calcium oxalate crystal nucleation and aggregation, crucial steps in stone formation. Moreover, EEMI demonstrated a low toxicity profile in acute toxicity assessments, affirming its safety. In an ethylene glycol-induced rat model, EEMI effectively restored serum and urinary parameters, indicating its ability to preserve kidney function and mitigate hyperoxaluria. These findings highlight the promise of EEMI as a potential natural remedy for kidney stone prevention and management, warranting further research and clinical studies.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Shaik Mohemmed Zeeshan Ali
M-Pharmacy,Department of Pharmacology,Safa College of Pharmacy, Kurnool
Dr. MD Sultan Ali Basha
Professor, Department of Pharmacology, Principal of Safa College of Pharmacy Safa College of Pharmacy, Kurnool.
Preethi Kuruva
Research scholar M-Pharmacy, Department of Pharmacology, Safa College of Pharmacy, Kurnool.
Gotla Anand
Research scholar M-Pharmacy, Department of Pharmacology, Safa College of Pharmacy, Kurnool.
D. Riyazunnisa
D. Riyazunnisa, M.Pharm, Associate Professor, Department of Pharmacology Safa College of Pharmacy, Kurnool.
Shaik Mahaboob Bee
Shaik Mahaboob Bee, M.Pharm Assistant Professor, Department of Pharmacology Safa College of Pharmacy, Kurnool