EXPLORING THE RELATIONSHIP BETWEEN URINARY TRACT INFECTION AND METABOLIC DISEASES IN PATIENTS WITH URINARY STONES

Main Article Content

Muhammad Idrees
Raza Muhammad
Sumaiya Noor
Syed Mohammad Usama
Taher Janoowala
Sadia Arif
Muhammad Umer Khan
Ayesha Amjad

Keywords

Urinary Tract Infection, Metabolic Diseases, Urinary Stones, Pakistan

Abstract

Background: Urinary Tract Infection (UTI) and metabolic diseases significantly impact global health, with urinary stones being influenced by various factors, including metabolic abnormalities.


Objective: This study's main goal was to find out how common urinary tract infections are in the area of Pakistan and how they interact with metabolic disorders in those who have kidney stones.


Methodology: The research was conducted from January to December 2022 at the medicine department of Saidu Group of Teaching Hospital, Swat, Pakistan, using a retrospective cohort approach. Retrospective reviews of medical records were used to gather data, such as the history of metabolic diseases, the composition of stones, and UTI episodes. Urine samples collected every 24 hours and blood analysis were among the laboratory procedures carried out. Using SPSS for statistical analysis, a significance threshold of p < 0.05 was established.


Results: The research, which included 162 individuals with kidney stones, revealed a gender distribution that was well balanced, with 48.14% (n = 78) men and 51.86% (n = 84) women. Urinary stone history (n=58; 35.80%), diabetes mellitus (n=47; 29.01%), hypercalciuria (39; 24.07%), and past UTIs (n-95; 58.64%) were also significantly prevalent in the clinical history. A strong correlation was seen between metabolic abnormalities, namely hypercalciuria, and UTI (p = 0.001). A significant correlation between UTI and hypercalciuria was shown by logistic regression analysis (OR: 3.87, p = 0.0002). There was a noteworthy correlation seen in stone composition, namely in calcium oxalate (OR: 1.89, p = 0.062).


Conclusion: The research highlights a noteworthy occurrence of urinary tract infections, metabolic disorders, and repeated instances of bladder stones in individuals diagnosed with urinary stones.

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