FREQUENCY OF LONG QT SYNDROME IN PATIENTS PRESENTING TO TERTIARY CARE HOSPITAL

Main Article Content

Zahoor Ahmad Khan
Salman Ahmad
Hameedullah
Zahid Aslam Awan

Keywords

Long QT syndrome, prevalence, QTC

Abstract

Background: Long QT syndrome is a myocardial repolarization disorder that results in long QT interval on the ECG.


Objective: The aim of this study is to determine the frequency of long QT syndrome in patients presenting to tertiary care hospital.


Materials and methods: This observational study was conducted at the department of cardiology, Hayatabad medical complex Peshawar from October 2014 to December 2021 to evaluate the prevalence of Long QT syndrome at admission and its influence on outcomes in CCU. The calculation of QTc using the formula by BAZETT, which suggests a range of >440 ms for males and >460 mm for females, was considered long. Furthermore, the illness's particulars, clinical observations and laboratory parameters were examined.


RESULTS: A total of 150 patients were enrolled in this study.There were 72 females and 78 males. At the time of admission to the CCU, Long QT Syndrome was frequently observed (32%). which dropped to 20.5% on day 3. Patients who suffered from long QT syndrome were found to have a high likelihood of adverse outcomes and were more likely to be admitted to the CCU of the hospital.


Conclusion: Our Study showed   a high incidence of Long QT syndrome (32%) and was more likely to have adverse effects and had a higher admission in CCU.

Abstract 72 | PDF Downloads 28

References

1. Aerssens J, Paulussen AD. Pharmacogenomics and acquired long QT syndrome. Pharmacogenomics. 2005;6(3): 259-70
2. Sarganas G, Garbe E, Klimpel A, Hering RC, Bronder E, Haverkamp W. Epidemiology of symptomatic drug-induced long QT syndrome and torsade de pointes in Germany. Europace. 2014;16(1): 101-8
3. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010;55(9): 934-47
4. Barra S, Agarwal S, Begley D, Providência R. Post-acute management of the acquired long QT syndrome. Postgrad Med J. 2014;90(1064): 348-58
5. Ramalho D, Freitas J. Drug-induced life-threatening arrhythmias and sudden cardiac death: A clinical perspective of long QT, short QT and Brugada syndromes. Rev Port Cardiol (Engl Ed). 2018;37(5): 435-46
6. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J.2015;36(41): 2793-867
7. Khan IA. Clinical and therapeutic aspects of congenital and acquired long QT syndrome. Am J Med. 2002;112(1): 58-66
8. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis. 1988;31(2): 115-72
9. Scheuermeyer FX, Innes G, Grafstein E, Chard R, Vandenberg S, Cheyne J, et al. Emergency department patients with a prolonged corrected QT interval do not have increased thirty-day mortality. Acad Emerg Med. 2019;26(7): 818-22.
10. Pickham D, Helfenbein E, Shinn JA, Chan G, Funk M, Weinacker A, et al. High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: results of the QT in Practice (QTIP) Study. Crit Care Med. 2012;40(2): 394-9
11. Haugaa KH, Bos JM, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ. Institution-wide QT alert system identifies patients with a high risk of mortality. Mayo Clin Proc. 2013;88(4): 315-25
12. Kozik TM, Wung SF. Acquired long QT syndrome:frequency, onset, and risk factors in intensive care patients. Critical Care Nurse. 2012 Oct 1;32(5):32-41
13. George TK, David Chase, Peter JV, Satytendra S, Kavitha R, George LR, et al. Association between aprolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit. Indian J Critical Care Med. 2005;19(6):326-32.
14. Mabasa VH, Yokoyama S, Damen Man JM. Analysis of orders for QTc-prolonging medication for intensive and cardiac care unit patients with preexisting QTc prolongation (QTIPPP study). The Canadian J Hospital Pharma. 2011 Nov;64(6):412-8
15. Kozik TM, Wung SF. Acquired long QT syndrome: frequency, onset, and risk factors in intensive care patients. Critical Care Nurse. 2012 Oct 1;32(5):32-41
16. George TK, David Chase, Peter JV, Satytendra S, Kavitha R, George LR, et al. Association between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit. Indian J Critical Care Med. 2005;19(6):326-32
17. Tisdale JE, Wroblewski HA, Overholser BR,Kingery JR, Trujillo TN, Kovacs RJ. Prevalence ofQT interval prolongation in patients admitted to cardiac care units and frequency of subsequent administration of QT interval-prolonging drugs. Drug Saf. 2012 Jun 1;35(6):459-70
18. Pickham D, Helfenbein E, Shinn JA, Chan G, Funk M, Weinacker A, et al. High prevalence of corrected QT interval prolongation in acutely ill patients I associated with mortality: results of the QT in Practice (QTIP) Study. Critical Care Med. 2012 Feb 1;40(2):394-9
19. Haugaa KH, Bos JM, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ. Institution-wide QT alert system identifies patients with a high risk of mortality. Mayo Clinic Proceedings. 2013 Apr 1;88(4):315-25