IMMUNOLOGICAL BIOMARKERS AND PROGNOSIS OF ENDOMETRIAL CANCER: A META-ANALYSIS
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Keywords
Endometrial Cancer, miR-421, miR-548ag, Biomarkers, Meta Analysis
Abstract
Objective: This research is to explore the relationship in immune related biomarkers and prognosis in endometrial cancer (EC).
Method: This article searched relevant databases and literature, and ultimately included 13 articles for meta-analysis. During the literature screening process, irrelevant literature, as well as literature published in comments and academic conferences were excluded. Among the included literature, there are 6 articles related to miR-421 and 7 articles related to miR-548ag. The data processing of Meta-analysis adopts statistical methods.
Result: The combined specificity and SROC curve results of meta-analysis showed that miR-421 and miR-548ag possess high diagnostic value for EC. At the same time, sensitivity analysis was conducted on the overall survival rate of OS, and no significant impact was found on combined HR and 95% CI in any study. This indicates that miR-421 and miR-548a possess an essential influence on the prognosis of EC and demonstrates the reliability of this analysis.
Conclusion: The relevant outcomes suggest that miR-421 and miR-548ag may be biomarkers for the prognosis of endometrial cancer. These findings have important guiding significance for a deeper understanding of the pathogenesis, pathological and physiological changes, and clinical treatment of endometrial cancer. It is essential to conduct more research for validating the role of these biomarkers in the prognosis of endometrial cancer.
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Emama Arshad Abbasi
Houseofficer, Combined Military Hospital, Muzaffarabad, AJK, Pakistan
Nisha Hamid Awan
Resident Medicine, Combined Military Hospital, Muzaffarabad, AJK, Pakistan
Soffia Khursheed
Assistant Professor Histopathology, Pakistan Institute of Medical Science, Islamabad, Pakistan
Sohail Ahmed
Post Graduate Student, Yangtze University,Hubei province ,Jingzhou, China
Jahanzeb Ahmed
Trainee General Surgery, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Amna Akbar
Medical Officer, District Headquarter Hospital Jhelum Valley, AJK, Pakistan
Sabahat Tasneem
Public Health Professional (MSPH), Health Services Academy, Islamabad, Pakistan
Mohammad Saleem khan
FRCP(Glasgow), FRCP(Edin),FRCP ( Ireland), FACP, FPSIM, FCPS ,MCPS ,MBBS(Gold Medalist), Chief Consultant Physician /Head of Department Of Medicine DHQ Teaching Hospital Kotli AJK, Pakistan
Sarosh Khan Jadoon
Resident Surgeon, Combined Military Hospital, Muzaffarabad, AJK, Pakistan