THE SHORT-TERM EFFECTIVENESS OF LEFLUNOMIDE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS

Salma Zeb; Zafar Mehmood; Sumaira Bakhtiar; Muhammad Bilal Awan; Yaseen Khan; Zia ullah Chamkani

doi:10.53555/jptcp.v30i18.3217

Salma Zeb
Zafar Mehmood
Sumaira Bakhtiar
Muhammad Bilal Awan
Yaseen Khan
Zia ullah Chamkani

Keywords

(Leflunomide), (DMARD ) Disease Modifying Anti-Rheumatic Drugs

Abstract

Objective: To assess leflunomide's short-term effectiveness in patients with active rheumatoid arthritis.

Study design: A Descriptive Cross Sectional Study

Duration and place of study: Department of Medical B Unit Lady Reading’s hospital Peshawar. from 1st June 2022 to 31st May 2023

Methodology: The Medical B Unit of MTI Lady Readings Hospital in Peshawar hosted this descriptive cross-sectional research, Over a period of one year from June 1, 2022, to May 31, 2023. This research comprised 147 individuals with active RA (DAS28>5.1). Patients enrolled in the trial were administered 20 mg of leflunomide daily. Using the European League against Rheumatisms (EULAR) standards, the effectiveness of both medications was evaluated after six months of therapy in terms of DAS 28 scores.

Results: Following a 6-month course of therapy with leflunomide, 47 patients saw no response, while 100 patients (68.02%) showed a moderate response. Leflunomide caused a mean change in DAS 28 score of 1.79 ±0.75.

Conclusion: Based on EULAR response criteria, leflunomide showed a considerable short-term effectiveness in RA patients.

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Published

Oct 25, 2023

DOI https://doi.org/10.53555/jptcp.v30i18.3217

How to Cite

Salma Zeb, Zafar Mehmood, Sumaira Bakhtiar, Muhammad Bilal Awan, Yaseen Khan, & Zia ullah Chamkani. (2023). THE SHORT-TERM EFFECTIVENESS OF LEFLUNOMIDE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS. Journal of Population Therapeutics and Clinical Pharmacology, 30(18), 1010–1014. https://doi.org/10.53555/jptcp.v30i18.3217

Issue

Vol. 30 No. 18 (2023): JPTCP

Section

Articles

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