PATTERN OF ANTIBIOTIC RESISTANCE IN STROKE PATIENTS WITH UTI AND ITS DETERMINANTS

Main Article Content

Salma Zeb
Sumaira Bakhtiar
Zafar Mehmood
Laila Zeb
Muhammad Bilal Awan
Zia Ullah Chamkani

Keywords

Stroke, Urinary Tract Infection, Antibiotic Resistance, Microorganisms

Abstract

Background: Stroke is the world's second leading cause of mortality and morbidity. Stroke survivors usually have UTIs along with other infections as they weaken the immune system. UTIs are common after a stroke and usually result in death or disability.


Objective: The main objective of this study is to discover and characterise the pattern of antibiotic resistance in UTIs among 80 stroke patients.


Study Design:  Descriptive cross-sectional study


Place and Duration: This Study was conducted at the Department of Medicine, Lady Reading Hospital, and Peshawar between September 2022 and February 2023


Material and Methods: The study included 80 patients over the Age of 18 of both genders. Urine cultures were collected before antibiotics were administered to UTI-symptomatic stroke patients. Relevant data was entered in a pre-designed proforma to adjust for confounders and bias.


Results: The study had 80 patients, 45 (56.25%) male and 35 (43.75%) female. Patients had a mean age of 62.4±10.3 years. 70% of patients had ischemic strokes, while 30% had hemorrhagic strokes. The average NIHSS score was 9.7±3.6. Many patients (35%) had recurrent strokes and 95% needed bladder catheterisation. Most patients (72.5%) had diabetes. E. coli caused 45 (56.25%) UTIs. (90%)  were sensitive to Carbapenems, nitrofurantoin, and fosfomycin only.


Conclusion: This study, focusing on urinary tract infections (UTIs) in stroke patients, has disclosed essential elements of patient demographics, clinical profiles, causative microorganisms, and treatment resistance trends.

Abstract 132 | pdf Downloads 66

References

1. Warlow CJTL. Epidemiology of stroke. 1998;352:S1-S4.
2. Lopez AD, Mathers CD, Ezzati M, Jamison DT. Murray CJJTl. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. 2006;367(9524):1747-57.
3. Shi K, Wood K, Shi F-D, Wang X, Liu QJS. Neurology v. Stroke-induced immunosuppression and poststroke infection. 2018;3(1).
4. Stanley D, Mason LJ, Mackin KE, Srikhanta YN, Lyras D, Prakash MD et al. Translocation and dissemination of commensal bacteria in post-stroke infection. 2016;22(11):1277–84.
5. Chamorro A, Urra X, Planas AMJS. Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression. 2007;38(3):1097–103.
6. Davenport R, Dennis M, Wellwood I, Warlow CPJS. Complications after acute stroke. 1996;27(3):415–20.
7. Aslanyan S, Weir C, Diener HC, Kaste M, Lees KR, Committee GIS et al. Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial. 2004;11(1):49–53.
8. Rocco A, Pasquini M, Cecconi E, Sirimarco G, Ricciardi MC, Vicenzini E et al. Monitoring after the acute stage of stroke: a prospective study. 2007;38(4):1225–8.
9. Stott D, Falconer A, Miller H, Tilston J, Langhorne PJQAIJoM. Urinary tract infection after stroke. 2009;102(4):243–9.
10. Copp HL, Shapiro DJ, Hersh AL. National ambulatory antibiotic prescribing patterns for pediatric urinary tract infection, 1998-2007. Pediatrics. 2011;127:1027–33.
11. Molazade A, Shahi A, Gholami M, Najafipour S, Jafari S, Mobasheri F, et al. The antibiotic resistance pattern of gram-negative Bacilli isolated from urine cultures of adult outpatients admitted to Vali Asr Hospital of Fasa Clinical Laboratory in 2012-13. J Jahrom Univ Med Sci. 2014;12:15–22.
12. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and therapeutics. 2015 Apr;40(4):277.
13. Copp HL, Shapiro DJ, Hersh AL. National ambulatory antibiotic prescribing patterns for pediatric urinary tract infection, 1998-2007. Pediatrics. 2011;127:1027–33.
14. Molazade A, Shahi A, Gholami M, Najafipour S, Jafari S, Mobasheri F, et al. The antibiotic resistance pattern of gram-negative Bacilli isolated from urine cultures of adult outpatients admitted to Vali Asr Hospital of Fasa Clinical Laboratory in 2012-13. J Jahrom Univ Med Sci. 2014;12:15–22.
15. Moghadas A, Iranian G. Asymptomatic urinary tract infection in pregnant women. Iran J Pathol. 2009;4:105–8.
16. Forbes BA, Sahm DF, Weissfeld AS. Study Guide for Bailey and Scott's Diagnostic Microbiology-E-Book: Elsevier Health Sciences. 2016.
17. Rezatofighi SE, Mirzarazi M, Salehi M. Virulence genes and phylogenetic groups of uropathogenic Escherichia coli isolates from patients with urinary tract infection and uninfected control subjects: a case-control study. BMC Infectious Diseases. 2021 Dec;21:1-1.
18. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. The American journal of medicine. 2002 Jul 8;113(1):5-13.
19. Akhtar N, Rahman R, Sultana S. Antimicrobial sensitivity pattern of Escherichia coli causing urinary tract infection in Bangladeshi patients. American Journal of Microbiological Research. 2016;4(4):122-5.
20. Farajnia S, Alikhani MY, Ghotaslou R, Naghili B, Nakhlband A. Causative agents and antimicrobial susceptibilities of urinary tract infections in the northwest of Iran. International journal of infectious diseases. 2009 Mar 1;13(2):140-4.
21. Shaifali I, Gupta U, Mahmood SE, Ahmed J. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North American journal of medical sciences. 2012 Apr;4(4):163.
22. Okonko IO, Ijandipe LA, Ilusanya AO, Donbraye-Emmanuel OB, Ejembi J, Udeze AO, Egun OC, Fowotade A, Nkang AO. Detection of urinary tract infection (UTI) among pregnant women in Oluyoro Catholic Hospital, Ibadan, South-Western Nigeria. Malaysian Journal of Microbiology. 2010;6(1):16-24.
23. Faujdar SS, Bisht D, Sharma A. Antibacterial activity of Syzygium aromaticum (clove) against uropathogens producing ESBL, MBL, and AmpC beta-lactamase: Are we close to getting a new antibacterial agent? Journal of family medicine and primary care. 2020 Jan;9(1):180.
24. Bullens M, de Cerqueira Melo A, Raziq S, Lee J, Khalid GG, Khan SN, Zada A; Atta-Ur-Rehman; Wailly Y, Zeshan SM, Saad NJ, Gil-Cuesta J, Williams A. Antibiotic resistance in patients with urinary tract infections in Pakistan. Public Health Action. 2022 Mar 21;12(1):48-52.
25. Mohammed D, Isa HM, Ali MF. Microbial Etiology and Antibiotic Resistance Patterns of Urinary Tract Pathogens in Hospitalized Infants in Bahrain: A Tertiary Care Center Experience. Cureus. 2022 Sep 16;14(9):e29236.