TASTE MASKING OF BITTER DRUG USING ION EXCHANGE RESINS

Abstract

The objective of present research work was to masking the bitter taste of Levamisole HCl with strong cation exchange resin i.e Tulsion 343. The complex formation of drug with Tulsion 343 was carried out using batch method to block the functional group responsible for causing bitter taste.

FTIR spectra, X-RD spectra,

DSC analysis, and decomplexation studies shows evidences of complex formation. Drug release from drug: resin complex was obtained at salivary pH (6.8) and gastric pH (1.2).  Accelerated stability study (AST) on drug: resin complexes were performed by keeping sample of complexes at 40^º C for period of 1 month.

The efficient drug loading was evident in batch process using Tulsion-343 with a drug: resin ratios 1:1, 1:1.5, and 1:2 (% w/w). Drug release from selected drug: resin complex at salivary pH was insufficient to impart bitter taste. Drug release has no significant effect using different media at same pH: salivary pH (phosphate buffer pH 6.8 and simulated salivary fluid) and at gastric pH (0.1 N HCl and simulated gastric fluid). Drug: resin complexes were found stable at elevated temperature.

Depending upon percent complexation, release study at different pH, Levamisole Hydrochloride: Tulsion-343 complex of ratio 1:1 (%w/w) was gives good results