DEVELOPMENT OF MOUTH DISSOLVING TABLETS USING DIFFERENT TECHNIQUES

Abstract

Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study three different methods direct compression, effvercent and sublimation in formulation of mouth dissolving tablets of Granisteron HCl. Total Six formulations using various super disintegrants, subliming agents and different ratio of sodium bicarbonate: citric acid were prepared. All prepared formulations were evaluated for physico- chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 20 to 35 s. Comparative evaluation of three methods showed direct compression method is a better than effervescent method than sublimation method as its formulations rapidly disintegrate in oral cavity. In vitro cumulative percentage drug release for formulations prepared by direct compression with explotab super disintegrants shows 98.79%, effervescent method with 12:6 ratios of sodium bicarbonate: citric acid shows 95.05% while sublimation method using camphor shows 92.13% releases in 12 min. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism