FREQUENCY OF LEIOMYOMA IN FEMALES PRESENTING WITH INFERTILITY AND ITS ASSOCIATION WITH SERUM VITAMIN D3 LEVEL

Main Article Content

Rabia
Dania Nayyer
Tayyaba Rashid
Anam Rashid
Noor ul Huda
Saba Ijaz

Keywords

Uterine leiomyoma, Infertility, Serum vitamin D3

Abstract

Background: In women of reproductive age, uterine fibroid, a benign tumour of the uterine smooth muscle, is a common cause of menorrhagia and dysmenorrhea. Fibroid etiopathogenesis involves numerous factors. The aetiology of fibroids is influenced by hormonal variables, although other causes are still unknown. According to some theories, uterine fibroids form as a result of an inappropriate response to tissue repair that alters the formation of extracellular matrix. Vitamin D may be able to prevent this abnormal response by controlling it.


Objective: The study was conducted to determine the frequency of leiomyoma in patients presenting with infertility and to compare the mean serum vitamin D3 levels in females with and without leiomyoma.


Study design: A cross-sectional study


Place and Duration:  This study was conducted in Jinnah Hospital, Lahore from July 2021 to January 2022


Methodology: Using a non-probability, consecutive sampling method 101 cases of 18 to 40 years presenting with infertility were included in the study. These patients were then divided into two groups on the bases of ultrasound findings. The group I included the patients with uterine fibrosis and group II included those without uterine fibrosis.  Later, 5 ml of blood was drawn from each patient under an aseptic measure and was sent to the lab for measurement of serum vitamin-D3 levels. All the collected data was entered and analyzed into SPSS version 25


Results: The findings of this study revealed that the mean  BMI was 27.99±5.95 kg/m2,  mean serum vitamin-D3 levels was 31.67±4.179 ng/ml and mean age was calculated as 30.65±3.48 years.  It was observed that 24.8 %( n=25) were in the age group of 18-28 years. There were 56.44% (n=57) females from rural areas, and the Frequency of uterine leiomyoma was 15.8 % (n=16). The t-test of association revealed that patients with uterine leiomyoma had lesser mean Vit D3 levels compared to the patients without uterine leiomyoma with a significant p-value <0.05


Conclusion: We found that the frequency of uterine leiomyoma was 15.8 % (n=16).  Both groups were compared for mean serum vitamin-D3 levels. P=0.000. It is concluded from the study results that the mean percentage of serum vitamin D3 level was significantly lower in uterine leiomyoma patients.

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