HELICOBACTER PYLORI INFECTION AND SERUM IRON PROFILE: A CASE CONTROL STUDY AT TERTIARY CARE HOSPITAL NAWABSHAH, SINDH PAKISTAN

Main Article Content

Bashir Ahmed Khuhro
Mohsin Ali
Riaz Hussain Khokhar
Khawar Hussain
Komal
Nasrullah Aamer

Keywords

H-PYLORI SERUM IRON SERUM FERRITIN IRON PROFILE

Abstract

OBJECTIVE “Helicobacter pylori (H. pylori) infection is the most common chronic infection. The aim of this cross-sectional study was to determine the association between iron profile, serum iron, ferritin level, and total serum iron binding capacity (TIBC) in adults and adolescents with positive H. pylori infection. 


METHODOLOGY This study was conducted this case control study in the Department of Medicine, PUMHSW Nawabshah, Shaheed Benazirabad Sindh Pakistan from April 2022 to March 2023. A total of 200 patients of both sexes with seropositive H. pylori confirmed by the presence of stool specific antigen (HpSAg) or positive antibodies to Helicobacter pylori in the blood were enrolled as group A. Another 200 subjects with negative H. pylori were recruited to adjust for age and sex and designated as group B, aged 18 to 60 years of both sexes.Blood was drawn for hematocrit (Hct), hemoglobin (Hb), and iron profile. Data were noted in a predesigned, prestructured proforma, and confidentiality was maintained. All data variables were analyzed using SPSS 22.0 (USA).


RESULTS Out of 256 subjects, 128 were in case group and 128 in control group. The mean age of case group was 37.8906 ± 11.69510 years and for control it was 37.5000 + 11.56018. Regarding the gender the 60 (46.9%) were male and 56 (43.8%) were female in case group. In study the mean iron level was 58.9530 + 24.77736 in H. pylori participants as and those who were negative H. pylori their mean serum iron was 68.1180 ± 18.06080; p-value: <0.001. Serum ferritin level was 112.7328± 105.16863 in H. pylori positive group as compared to control group that was 208.5980± 114.04281ng/dL; p-value: <0.001. The mean total iron-binding capacity was 331.7559 ± 67.79927 ug/dl.


 CONCLUSIONS The study results support a positive association between H. pylori and a low serum iron profile. Therefore, we recommended that in H. pylori positive patients should be investigated for iron profile.

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