EVALUATION OF ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF NATURAL HERBAL EXTRACT IN VARIOUS ANIMAL MODELS
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Keywords
Antioxidant, Natural Herbal Extract, Hepatoprotective, Various Animal Models
Abstract
In the ongoing examination, Wistar rodents that had their livers harmed via carbon tetrachloride (CCl4) were given stem watery concentrate of Caralluma europaea (AECe) to test for hepatoprotective properties. A 250 mg/kg body weight daily dose of a concentrated C. europaea solution was administered to these organisms for 14 days. The CCl4 dose (1 ml/kg) was given twice, on days 7 and 14. At the conclusion of the experiment, the rodents were all put to sleep, their blood was obtained for biochemical boundary evaluation, and they were slaughtered with their livers removed and measured. In light of the discoveries of this examination, C. europaea organization before openness to CCl4 organization had a good hepatoprotective impact in rodents. The organization of AECe (250 mg/kg) shows areas of strength for an impact by decreasing the progressions in these metabolic markers brought about by CCl4. Therefore, C. europaea may one day be a valuable spice for dealing with sicknesses like liver harming.
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Rohit
RKSD College of Pharmacy, Ambala Road , Kaithal, Haryana. 136027
Konda V V S Krishna
Government Polytechnic for Women, Srikakulam, Andhra Pradesh. 532005
Rahul Kumar Shaw
Dhanvantari College Of Pharmacy, Munnapatra, Chakla, Ormanjhi, Ranchi, Jharkhand. 835219
Dighe Rajendra Dnyandeo
K.B.H.S.S. Trust's Institute of Pharmacy , Malegaon , Nashik (M.S) 422009
Kiran Nathe
MVP College of Pharmacy, Nashik, Maharashtra. 422002
Mangesh Manikrao Kumare
Smt. Kusumtai Wankhede Institute of Pharmacy, Dhantoli, Katol, Nagpur, Maharashtra. 441302
Abhishek Banke
Sagar Institute of Research Technology & Science Pharmacy, Bhopal, Madhya Pradesh. 462041
Arjun Patidar
Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh. 456006