INSILICO, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES

Main Article Content

Arti J.Darode
Surajit Saha
Neelmani Chauhan
Nazia Malik
Dighe Rajendra Dnyandeo
Sumaiya Naaz
Seena KX
Sakshi Aole

Keywords

Quinolines, DNA Gyrase, p-Hydroxy benzaldehyde, Sodium acetate, Potassium hydroxide, Choroacetyl chloride, Choropropionyl chloride, Antimicrobial activity

Abstract

The purpose of this research is to functionalize to synthesise 4,7-disubstituted quinoline.Intially quinoline derivatives was docked using3U2D DNA Gyrase as a target for anti-bacterial activity by using schrodinger software, from the results obtained from docking only those compounds which shown potent activity were subjected for synthesis using facile method.The synthesized compounds wascharacterized by IR, NMR and Mass spectrometry,


The synthesized compounds (TM1-TM8) were screened for antibacterial activity studies at various concentrations of 5, 10, 25, 50 and 75mg/ml using DMF as a control against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Klebsiella pneumonia, by agar-well diffusion method. Ciprofloxacin was used as standard drug.


Among the synthesized compounds TM4shown moderate activity when compared with the standard, rest of the derivatives possesses weak antibacterial activity.

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