NELUMBO NUCIFERA LEAVES EXTRACT PARTIALLY REDUCES HIGH-FAT DIET INDUCED OBESITY IN EXPERIMENTAL RATS

Main Article Content

Konda V V S Krishna
Rukhsana M. Pinjari
Geeta N Lodhi
Allenki Venkatesham
Bembalkar
Vamseekrishna Gorijavolu
Firos A
Geeta Sahu

Keywords

Nelumbo Nucifera, Anti-obesity, Herbal, Leaf extract, High-fat diet

Abstract

Introduction: The global pursuit of reducing body fat among obese individuals has driven extensive research into identifying functional foods that can aid in combating excess body fat. One such focus has been on investigating the potential of Nelumbo nucifera (NN) leaf extract to address obesity-related concerns.


Objective: This study aims to assess the anti-obesity properties of Nelumbo nucifera leaf extract in rats subjected to a high-fat diet (HFD) that induces obesity.


Materials and Methods: Female albino rats were fed either a standard chow diet (CD) for 40 days to induce obesity. Different doses of NN leaf extract (100, 200, and 400 mg/kg, administered orally) were given daily to distinct treatment groups. Parameters including body weight (measured every 5 days), organ and body fat pad weights, body temperature, locomotor activities, as well as levels of total cholesterol, triglycerides, and glucose were evaluated on the 39th and 40th day of the study.


Results: Rats treated with the high dose (400 mg/kg) of NN leaf extract exhibited significant reductions in body weight, total cholesterol, triglyceride levels, and glucose levels. Additionally, these rats demonstrated increased locomotor activities and elevated body temperatures.


Conclusion: The supplementation of NN leaf extract, particularly at the high dose, effectively mitigated weight gain and positively impacted metabolic parameters in rats. These findings suggest the potential of NN leaf extract as a natural remedy for countering obesity, offering a promising herbal solution for individuals seeking to revert from obesity to a healthier state.

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