A Study of Effect on Weight Gain by High Dose Amino Acid Infusion Vs Low Dose Amino Acid Infusion in Preterm Very Low Birth Weight Infants Admitted in Nicu in A Tertiary Care Hospital

Mounika Suroju; Girish G. Joag; K.Mahendranath; Shreshta.B.R

doi:10.47750/jptcp.2023.30.16.010

Mounika Suroju

Junior Resident, Department of Paediatrics, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India

Girish G. Joag

Professor, Department of Paediatrics, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.

K.Mahendranath

Senior Resident, Department of Paediatrics, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.

Shreshta.B.R

Senior Resident, Department of Paediatrics, Krishna Institute of Medical Sciences Deemed to be University, Karad, Satara, Maharashtra, India.

Keywords

Early amino acid infusion EAA , Hospital based interventional study

Abstract

Background: Premature infants have higher mortality rates and are more prone to a variety of morbidities compared to term babies. The immaturity of the organs or functions is a contributing factor for many of the issues that preterm infants face. Hyaline membrane disease, patent ductus arteriosus, intraventricular haemorrhage, and metabolic issues including hypoglycaemia and NEC (necrotising enterocolitis) are some of the major complications/morbidities associated with premature birth. In addition, feed intolerance is a common gastrointestinal issue in preterm new-borns.
Aims and Objectives: To study, the effect of Early administration of High Dose amino acid infusion Vs Low Dose Amino Acid infusion on Weight Gain in Preterm very low birth weight infants admitted in NICU in Krishna Hospital, Karad and compare the effects.
Material and Methods: Study design: This was a hospital based interventional study done on 60 preterm vlbw infants admitted in to Neonatal ICU of tertiary care hospital of Karad from December 2020 to December 2022.
Statistical Analysis: The statistical analysis was done with SPSS software version 22. Mean, standard deviation was calculated for continuous variables to know their central tendency. Chi square test was used to test the association between categorical variables and t test for continuous variables. A p<0.05 was taken as significant.
Results: majority of the newborns were born at a gestational age of 32 nd -34th weeks in both the study groups (65.4%) (moderate preterms) and 28th -30th weeks of gestational age in both the study groups (34.6%) were very preterms, weight gain during hospital stay was compared among the two study groups, we observed statistically significant weight gain in high dose aminoacid group when compared to low dose amino acid group
Conclusion: This study suggests that high doses of Aminoacid infusions in the early Parenteral nutrition facilitate weight gain in preterm vlbw infants and also early recovery of birth weight with early achievement of full enteral feeding when compared to low doses of aminoacid infusion.

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References

1. American Academy of Pediatrics, Committee on Nutrition 1998 Nutritional needs of preterm infants. In: Kleinman R (ed) Pediatric Nutrition Handbook. American Academy of Pediatrics, Elk Grove Village, IL, pp 55–87
2. Ziegler E 1991 Malnutrition in the premature infant. Acta Paediatr Scand Suppl 374:5866
3. Lucas A 1995 Nutrition, growth and development of postdischarge, preterm infants. In: Hay Jr WW, Lucas A (eds) Posthospital Nutrition in the Preterm Infant. Ross Laboratories, Columbus, OH, pp 81–89
4. Ehrenkranz R, Younes N, Lemons J, Fanaroff AA, Donovan EF, Wright LL, Katsikiotis V, Tyson JE, Oh W, Shankaran S, Bauer CR, Korones SB, Stoll BJ, Stevenson DK, Papile LA 1999 Longitudinal growth of hospitalized very low birthweight infants. Pediatrics 104:280–289
5. Micheli JL, Schutz Y 1993 Protein. In: Tsang RC, Lucas A, Uauy R, Zlotkin S (eds) Nutritional
Needs of the Preterm Infant, Scientific Basis and Practical Guidelines. Caduceus Medical Publishers, Inc, Pawling, NY, pp 29–46
6. Hay Jr WW 1991 Nutritional requirements of the extremely-low-birthweight infant. In: Hay Jr WW (ed) Neonatal Nutrition and Metabolism. Mosby-Year Book, St. Louis, pp 361–391 7.
7. Lucas A, Morley R, Cole TJ 1998 Randomised trial of early diet in preterm babies and later intelligence quotient. BMJ 317:1481–1487
8. Wilson DC, Cairns P, Halliday HL, Reid M, McClure G, Dodge JA. Randomised controlled trial of an aggressive nutritional regimen in sick very low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed. 1997 Jul;77(1):F4–11.
9. Valentine CJ, Fernandez S, Rogers LK, Gulati P, Hayes J, Lore P, et al. Early aminoacid administration improves preterm infant weight. J Perinatol. 2009 Jun;29(6):428–32.Rocha, Gustavo et al. “Persistent pulmonary hypertension of non cardiac cause in a neonatal intensive care unit.” Pulmonary medicine vol. 2012 (2012): 818971. doi:10.1155/2012/818971
10. Tan M, Abernethy L, Cooke R. Improving head growth in preterm infants- -a randomised controlled trial II: MRI and developmental outcomes in the first year. Arch. Dis. Child. Fetal Neonatal Ed. 2008 Sep;93(5):F342–346
11. Freeman J, Goldmann DA, Smith NE, Sidebottom DG, Epstein MF, Platt R. Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units. N. Engl. J. Med. 1990 Aug 2;323(5):301–8.

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Published

Jun 23, 2023

DOI https://doi.org/10.47750/jptcp.2023.30.16.010

How to Cite

Mounika Suroju, Girish G. Joag, K.Mahendranath, & Shreshta.B.R. (2023). A Study of Effect on Weight Gain by High Dose Amino Acid Infusion Vs Low Dose Amino Acid Infusion in Preterm Very Low Birth Weight Infants Admitted in Nicu in A Tertiary Care Hospital. Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 84–90. https://doi.org/10.47750/jptcp.2023.30.16.010