COMPARATIVE EVALUATION OF BIOACTIVE GLASS AND PLATELET-RICH BIOMATERIALS ON SOFT-TISSUE HEALING IN MINOR ORAL SURGERY: A CLINICAL AND HISTO-BIOLOGICAL STUDY
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Keywords
Bioactive glass, platelet-rich fibrin, soft-tissue healing, minor oral surgery, wound healing.
Abstract
Accelerating soft-tissue healing following minor oral surgical procedures is essential to minimize postoperative discomfort and reduce healing-related complications. Bioactive glass and platelet-rich biomaterials, such as platelet-rich fibrin (PRF), have shown promising regenerative capabilities due to their bioactivity, growth-factor release, and influence on cellular proliferation.
Objective: To compare the clinical and histo-biological effects of bioactive glass and platelet-rich biomaterials on soft-tissue healing in patients undergoing minor oral surgery.
Methods: A randomized, split-mouth clinical trial was conducted on xx patients requiring symmetrical minor oral surgical procedures. Surgical sites were allocated into Group A (bioactive glass application) and Group B (PRF application). Clinical healing was evaluated at Days 3, 7, and 14 using the Landry, Turnbull, and Howley Wound Healing Index. Tissue samples from a subset of patients were collected at Day 7 for histo-biological assessment, including inflammatory cell count, fibroblast density, angiogenesis scoring, and epithelial thickness.
Results: Group B (PRF) showed significantly lower postoperative pain scores and superior early soft-tissue healing at Day 3 (p < 0.05). By Day 14, both groups demonstrated comparable clinical healing outcomes. Histologically, PRF demonstrated higher fibroblast activity and angiogenesis, while bioactive glass exhibited enhanced mineralized tissue deposition and improved epithelial maturation.
Conclusion: Both bioactive glass and PRF effectively enhance soft-tissue healing in minor oral surgery. PRF offers faster early healing due to its autologous growth-factor release, whereas bioactive glass demonstrates more pronounced tissue remodelling. A combination approach may yield synergistic healing benefits.
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Ahmad Ullah Rao
Dental surgeon Ava Seern Dental Clinic Bahawalpur Pakistan
Qurat ul Ain Malik
HOD and Assistant Professor Dental Materials, CIMS dental college, Multan, Pakistan
Abdul Ahad Khurshid
Senior Lecturer, Department of Oral Biology, CIMS Dental College, Multan, Pakistan
Saif Ullah
Assistant Professor, Oral and Maxillofacial Surgery Department, Mardan Medical Complex, Mardan, Pakistan
Akif Mahmud
Assistant Professor, Department of Oral & Maxillofacial Surgery, Women Dental College, Abbottabad, Pakistan
Namra Zahid
Dental surgeon Ava Seern Dental Clinic Bahawalpur Pakistan
