ADMINISTRATION OF PREOPERATIVE SUBMUCOSAL DEXAMETHASONE IN THIRD MOLAR SURGERY: A PROGRESSION TOWARDS ENHANCING QUALITY OF LIFE.
Main Article Content
Keywords
Dexamethasone; Third Molar Surgery; Swelling; Trismus; Quality of Life.
Abstract
Objective: To determine the efficacy of pre-operative submucosal administration of dexamethasone in surgery of impacted third molar (M3) teeth.
Methodology: Prospective comparative study was conducted at Dental Teaching hospital, from April 2024 to October 2024. A total 130 patients were enrolled in study and divided into two groups by simple randomization method. Group A was control group injected placebo and group B was case group injected 4mg dexamethasone immediately after induction of anesthesia through submucosal route. Efficacy was measured in terms of reduction in trismus, pain and inflammation in post-operative time. SPSS version 26 was used for data entry and analysis of variables.
Results: The mean pain score in Group A was 28.74 ± 5.21 compared with 22.56 ± 4.02 in Group B (p < 0.001). Mean swelling was 5.01 ± 1.35 mm in Group A and 3.42 ± 0.88 mm in Group B (p < 0.001). Mean trismus measured 24.89 ± 4.10 mm in Group A and 19.78 ± 2.91 mm in Group B, with Group B showing significantly less trismus (p < 0.001
Conclusion: Administering 4mg of dexamethasone through the submucosal route prior to mandibular third molar surgery can effectively reduce post-operative pain, swelling, and trismus.
References
2. Gümrükçü Z. The effects of piezosurgery and submucosal dexamethasone injection on post-operative complications after third molar surgery. JStomatol Oral Maxillofac Surg. 2019 Jun 1;120(3):182-7.
3. Erdil A, Akbulut N, Altan A, Demirsoy MS. Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofentrometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial. Clin Oral Investig. 2021 Apr;25:1849-57.
4. Desai Y, Ebenezer V, Balakrishnan R. Effect of Pre-Operative Use of Dexamethasone in Management of Inflammatory Complications in Surgical Removal of Third Molar–A Review Article. JPharmacSci Res. 2023 Mar 1;15(3):1047-8.
5. Shibl M, Ali K, Burns L. Effectiveness of pre-operative oral corticosteroids in reducing pain, trismus and oedema following lower third molar extractions: a systematic review. British Dent J. 2021 Jul 8:1-8.
6. Hiriyanna NM, Degala S. Objective and subjective comparison of submucosal and intravenous routes of single-dose preoperative dexamethasone for mandibular third molar surgery—a prospective randomized observer-blind study. Oral Maxillofac Surg. 2021 Jun;25:207-13.
7. Urechescu H, Tudor A, Costan VV, Talpos S, Pricop M. The role of submucosal dexamethasone injection in reducing complications after lower third molar surgery. Romanian J Oral Rehabil. 2022 Jan;14(1):169-74.
8. Ayub K, Fazal M. The Effectiveness of Submucosal Administration of Methylprednisolone and Dexamethasone in Comparison to Placebo after Third Molar Surgery: A Double Blinded, Parallel Arm Randomized Clinical Trial. Pak J Med Res. 2022;61(4):154-9.
9. Gümrükçü Z. The effects of piezosurgery and submucosal dexamethasone injection on postoperative complications after third molar surgery. J Stomatol Oral Maxillofac Surg. 2019 Jun;120(3):182-87.
10. Selvido DI, Bhattarai BP, Niyomtham N, Riddhabhaya A, Vongsawan K, Pairuchvej V et al. Review of dexamethasone administration for management of complications in postoperative third molar surgery. J Korean Assoc Oral Maxillofac Surg. 2021;47(5):341-50.
11. Alexander RE, Throndson RR. A review of perioperative corticosteroids use in dentoalveolar surgery. Oral Surg Oral Med Oral Path Oral RadiolEndod. 2000;90(4):406–15.
12. Dionne RA, Gordon SM, Rowan J, Kent A, Brahim JS. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. J Oral Maxillofac Surg. 2003;61(9):997–1003.
13. Shad S, Mahmud A, Shahnawaz A, Shah SMH, Farooq A, Mehmood S et al. Use of preoperative submucosal dexamethasone in third molar surgery: A step towards improvement in quality of life. J Ayub Med Coll Abbottabad. 2020;32(Suppl.1):607–11.
14. Sharma D, Tripathi GM, Tiwari R, Mishra A. Effect of submucosal administration of dexamethasone on postoperative discomfort after third molar surgery. National Journal of Maxillofacial Surgery. 2024 May 1;15(2):288-94.
15. Naik VG, Shankar MR, Agarwal R, Rai KK, Karande A, Humne A. Submucosal Infiltration versus Intravenous Administration of Dexamethasone in Decreasing Post-operative Inflammatory Sequelae after Third Molar Surgery-A Comparative Study. Annals of Maxillofacial Surgery. 2024 Jul 1;14(2):141-6.
16. Ahmed S, Ashraf U, Shaikh AH, Jamil S, Zaidi SJ, Baig QA. Efficacy of submucosal versus pterygomandibular dexamethasone injection in surgical extraction of the impacted lower third molar. Journal of Bahria University Medical and Dental College. 2024 Jul 23;14(03):174-9.
17. Koç O, Er N, Karaca Ç, Bilginaylar K. Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery. BMC Oral Health. 2024 Aug 30;24(1):1018.
18. Grossi GB, Maiorana C, Garranmone RA, Borgonovo A, Beretta M, Farronato D, et al. Effect of submucosal injection of Dexamethasone on postoperative discomfort after third molar surgery: A prosective study. J Oral Maxillofac Surg. 2007;65(11):2218–26.
19. Manavadaria Y, Vachhani M, Patel S, NS K. Comparing the Efficacy of Dexamethasone Injection by Submucosal, Intravenous and Intramuscular Routes in Minimizing Post-Operative Discomfort After Mandibular Third Molar Surgery-A Randomized Controlled Trial. Journal of Contemporary Clinical Practice. 2025 Jul 26;11:747-51.
20. Saeidi A. Dispensing Dexamethasone Submucosal and Intravenous Subsequent the Surgical Elimination of the Third Molar and Contrasting the Effectuality of the Mode of Delivery. Journal of Pharmacy and Bioallied Sciences. 2025 Sep 1;17(Suppl 3):S2754-6.
