HEPATOPROTECTIVE POTENTIAL OF ACTINIDIA DELICIOSA AGAINST CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN ALBINO RATS
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Keywords
Actinidia deliciosa, carbon tetrachloride, hepatoprotective, oxidative stress, liver enzymes, antioxidant activity
Abstract
This research examines the protective capabilities of alcoholic extract derived from Actinidia deliciosa (kiwi fruit) against hepatic damage induced by carbon tetrachloride (CCl₄) in albino rats. The investigation incorporated biochemical parameter analysis and histopathological examination to evaluate the extract’s hepatoprotective efficacy. Male albino rats were organized into distinct experimental groups and subjected to CCl₄ exposure to induce liver injury, with concurrent administration of either Actinidia deliciosa extract or standard hepatoprotective agent silymarin. The study assessed critical hepatic markers, including serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), alkaline phosphatase (ALP), and total bilirubin. Results demonstrated that ethanolic extract of Actinidia deliciosa significantly ameliorated CCl₄-induced alterations in biochemical parameters, with the lower dose (200 mg/kg) exhibiting greater efficacy than higher doses (400 mg/kg), and in some instances surpassing the standard reference drug silymarin. The extract also displayed substantial antioxidant activity in DPPH radical scavenging assays, with an IC₅₀ value of 305 μg/mL compared to silymarin’s 585 μg/mL. Histopathological examination supported these findings, showing preservation of normal hepatic architecture in extract-treated specimens. This investigation provides compelling evidence supporting the potential therapeutic application of Actinidia deliciosa in managing hepatic disorders characterized by oxidative damage.
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Sunil Kumar
M. Pharmacy Student, Faculty of Pharmaceutical Sciences, Motherhood University, Dehradun Road, Karoundi village, Bhagwanpur post, Roorkee Tehsil, Haridwar Distt.,
Kokkula Pavan Kumar
Associate Professor, Faculty of Pharmaceutical Sciences, Motherhood University, Dehradun Road, Karoundi village, Bhagwanpur post, Roorkee Tehsil, Haridwar Distt., Uttarakhand, India 247661.
Yella Sirisha
Professor, Faculty of Pharmaceutical Sciences, Motherhood University, Dehradun Road, Karoundi village, Bhagwanpur post, Roorkee Tehsil, Haridwar Distt., Uttarakhand, India 247661.