AN EVALUATIVE STUDY OF THE COMPARISON OF CA-125 AND SERUM TOTAL PROTEIN IN THE PATIENT POSITIVE FOR HCV AND HBsAg: A CROSS-SECTIONAL STUDY
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Keywords
CA-125, liver disease, HCV, HBsAg, total protein.
Abstract
Background: CA-125 is an essential part of MUC16, a mucin glycoprotein, which is used as a tumor marker for various diseases like ovarian carcinoma, pancreatic malignancy, etc. Its elevated level can also be seen in patients with liver cirrhosis. Elevated CA-125 levels can be associated with decreased synthesis of serum total protein because of impairment of the liver’s function.
Aim: The purpose of the study is to find out the level of CA-125 and correlate it with serum total protein in the patients positive for viral hepatitis C and hepatitis B surface antigen.
Method: The study was carried out over a 12-month period at the biochemistry department of HIMS, Dehradun. Patients with complications of liver disease were recruited in this study on the basis of exclusion and inclusion criteria. Serum CA-125, serum total protein, albumin, and globulin were estimated for those patients who had liver problems and were positive for HCV and HBsAg.
Result: This research observed the higher value of CA-125 in HBsAg-positive patients than in HCV-positive patients. And CA-125 has a negative correlation with serum total protein.
Conclusion: Serum CA-125 estimation in patients who are positive for HCV and HBsAg would be of advantage to the clinicians for assessing the severity of the liver disease.
References
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Apoorva Bansal
Department of Biochemistry, RMCH, Bareilly.
Pooja Vashistha
Department of Biochemistry, RMCH, Bareilly.
Archana Prakash
Department of Biochemistry, SRHU Jollygrant Dehradun.
Rohit Gupta
Department of Gastroenterology, SRHU Jollygrant Dehradun.
NS Jayla
Department of Biochemistry, SRHU Jollygrant Dehradun.