STUDY OF CORRELATION BETWEEN SEVERITY OF UROLITHIASIS AND LABORATORY PARAMETERS AND THEIR IMPLICATIONS IN DETERMINING PROBABLE RISK PROFILES.
Main Article Content
Keywords
Stone multiplicity, Urinary stones, urolithiasis
Abstract
Introduction: Urolithiasis is a severe health problem and significantly increases the national health expenditures in almost all regions. During the last three decades, the incidence of urinary stones has steadily increased, suggesting that specific constant metabolic and urinary parameters are associated with stone formation. This study aims to identify parameters of the patient's serum, urinary, and radiological clinical presentations and assess the clinical severity of stone disease based on this information.
Materials and Methods: An observational study was conducted by the Department of General Surgery at the Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, for 12 months. The authors analyzed a total of 80 patients suffering from urolithiasis. The data were compiled from all serum and urinary examinations and radiological scans collected within one month before surgery after obtaining written informed consent and ethical clearance. Analysis of variance (ANOVA) was used to compare more than two categories, and the Spearman test was used to determine correlations.
Results: The multiplicity of stones was positively correlated with the side of stones in the upper tract (r = 0.450, P < 0.01), large stone volume (r = 0.272, P < 0.05), stone recurrence, and urinary parameters. Stone sides in the upper tract were positively correlated with upper tract obstruction sides (r = 0.573, P < 0.01) and large stone volume (r = -0.242, P < 0.01). Several variables were positively correlated with the number of obstructions in upper tracts with large stone volumes (r = -0.787, P < 0.01).
Conclusion: The study concluded that the serum panel and urinary profile were strongly associated with urinary tract obstructions and the total stone volume. These factors acted as harbingers of complicated stone patterns.
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Pranav Prakash
Department of General Surgery, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
Shikhar Agarwal
Department of Urology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
Archana Prakash
Department of Biochemistry, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
Anita Sharma
Department of Biochemistry, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
Ashok Kumar Dogra
Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, UT.
Sanjay Dvivedi
Department of General Surgery, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India