MINIMALLY INVASIVE APPROACHES IN ESOPHAGEAL CANCER SURGERY

Main Article Content

Kamran Ahmad
Fazal Ghani
Kamran Hakeem Khan
Shafiq Ur Rahman
Khalil Ur Rehman
Aurangzeb Shaikh

Keywords

Minimally invasive, esophageal cancer, surgery, outcomes

Abstract

Background: Esophageal cancer continues to present a worldwide health problem because squamous cell carcinoma and adenocarcinoma incidence rates have been increasing globally. Medical professionals base treatment decisions on surgical resection methods whereas open procedures cause important risks throughout the patient's recovery period. The development of laparoscopic thoracoscopic robotic-assisted esophagectomy represents cutting-edge procedures which improve patient results through minimized complications combined with reduced hospital durations as well as accelerated recovery times. Specialized healthcare institutions now use these techniques at greater rates due to recent enhancements which warrant sustained assessments on their safety performance relative to conventional open procedures.


Objectives: The goal of this evaluation explores the performance of minimally invasive esophagectomy (MIE) versus open esophagectomy to analyze post-operative complications and hospital stay duration and oncological benefits to determine MIE's impact on survival rates and general well-being of patients diagnosed with esophageal cancer.


Study design: A Retrospective Cohort Study


Place and duration of study. Department of Surgery QHAMC, Nowshera Medical college ,Nowshera from july 2021 to Dec 2021


Methods: A total of 200 patients who received esophagectomy treatment for esophageal cancer were included in this research and they underwent either minimally invasive or open surgical procedures. The patient selection process started with limited esophageal cancer patients who did not show metastatic signs. The data collection process included demographic information in addition to perioperative variables and post-surgical complications. All statistical determinations were conducted using appropriate tests for significance while a p-value smaller than 0.05 indicated statistical significance. The researchers calculated the mean values together with standard deviation to determine demographic distribution inequalities between study groups.


Results: The study included an assessment of 200 patients as part of its research. The participants in this study had an average age of 62.5 years with age distribution measured at 8.3 years. Post-operative complications reduced and hospital stay shortened statistically in patients who received the minimally invasive approach rather than the traditional open approach (p=0.03 / p=0.01). The incidence of pulmonary infections reduced in patients who underwent MIE surgery which produced statistical significance (p=0.02). Additionally the MIE approach cut the average hospital stay duration by 3.5 days. The number of lymph nodes retrieved as well as margin clearance metrics produced equivalent results between both treatment groups (p=0.07). Quality-of-life scores in patients undergoing MIE proved superior than open surgery results (p=0.04) even though the one-year survival rates remained similar (p=0.12). The results demonstrate that minimally invasive esophagectomy maintains safety measures along with effectiveness for esophageal cancer treatment.


Conclusion: Esophageal cancer surgery based on minimally invasive approaches leads to reduced complications after operations and shorter hospital stays with identical oncologic results. Specialized facilities now routinely utilize these techniques although providing initial challenges to learn for new practitioners. Multi-center studies and long-term follow-up need to be intensified to confirm the exact survival and recurrence rate advantages.


 

Abstract 74 | Pdf Downloads 17

References

1. Zhang Y, Dong D, Cao Y, Huang M, Li J, Zhang J, Lin J, Sarkaria IS, Toni L, David R, He J. Robotic versus conventional minimally invasive esophagectomy for esophageal cancer: a meta-analysis. Annals of surgery. 2023 Jul 1;278(1):39-50.
2. Esagian SM, Ziogas IA, Skarentzos K, Katsaros I, Tsoulfas G, Molena D, Karamouzis MV, Rouvelas I, Nilsson M, Schizas D. Robot-assisted minimally invasive esophagectomy versus open esophagectomy for esophageal cancer: A systematic review and meta-analysis. Cancers. 2022 Jun 29;14(13):3177.
3. Gottlieb-Vedi E, Kauppila JH, Mattsson F, Lindblad M, Nilsson M, Lagergren P, Rouvelas I, Lagergren J. Long-term survival in esophageal cancer after minimally invasive esophagectomy compared to open esophagectomy. Annals of surgery. 2022 Dec 1;276(6):e744-8.
4. Sugita Y, Nakamura T, Sawada R, Takiguchi G, Urakawa N, Hasegawa H, Yamamoto M, Kanaji S, Matsuda Y, Yamashita K, Matsuda T. Safety and feasibility of minimally invasive esophagectomy for elderly esophageal cancer patients. Diseases of the Esophagus. 2021 Mar;34(3):doaa083.
5. Tagkalos E, Van Der Sluis PC, Berlth F, Poplawski A, Hadzijusufovic E, Lang H, van Berge Henegouwen MI, Gisbertz SS, Müller-Stich BP, Ruurda JP, Schiesser M. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial). BMC cancer. 2021 Dec;21:1-2.
6. Sakamoto T, Fujiogi M, Matsui H, Fushimi K, Yasunaga H. Comparing perioperative mortality and morbidity of minimally invasive esophagectomy versus open esophagectomy for esophageal cancer: a nationwide retrospective analysis. Annals of surgery. 2021 Aug 1;274(2):324-30.
7. Fabbi M, De Pascale S, Ascari F, Petz WL, Fumagalli Romario U. Side-to-side esophagogastric anastomosis for minimally invasive Ivor-Lewis esophagectomy: operative technique and short-term outcomes. Updates in surgery. 2021 Oct;73(5):1837-47.
8. Kalff MC, Fransen LF, de Groot EM, Gisbertz SS, Nieuwenhuijzen GA, Ruurda JP, Verhoeven RH, Luyer MD, van Hillegersberg R, van Berge Henegouwen MI, Dutch Upper Gastrointestinal Cancer Audit group. Long-term survival after minimally invasive versus open esophagectomy for esophageal cancer: a nationwide propensity-score matched analysis. Annals of surgery. 2022 Dec 1;276(6):e749-57.
9. Linghu E. A new stage of surgical treatment: super minimally invasive surgery. Chinese Medical Journal. 2022 Jan 5;135(01):1-3.
10. Yang Y, Li B, Yi J, Hua R, Chen H, Tan L, Li H, He Y, Guo X, Sun Y, Yu B. Robot-assisted versus conventional minimally invasive esophagectomy for resectable esophageal squamous cell carcinoma: early results of a multicenter randomized controlled trial: the RAMIE trial.
11. Pather K, Mobley EM, Guerrier C, Esma R, Kendall H, Awad ZT. Long-term survival outcomes of esophageal cancer after minimally invasive Ivor Lewis esophagectomy. World Journal of Surgical Oncology. 2022 Feb 25;20(1):50.
12. Riccio F, Fujiwara H, Klarenbeek BR, Cuesta MA. 478. OVERVIEW ON USE OF THE TRANSCERVICAL MEDIASTINOSCOPIC APPROACH FOR MINIMALLY INVASIVE TREATMENT OF ESOPHAGEAL CANCER: ESTABLISHMENT OF INTERNATIONAL COLLABORATIVE GROUP. Diseases of the Esophagus. 2024 Sep;37(Supplement_1):doae057-220.
13. Dumoulin FL, Hildenbrand R, Oyama T, Steinbrück I. Current trends in endoscopic diagnosis and treatment of early esophageal cancer. Cancers. 2021 Feb 11;13(4):752.
14. Sihag S, Ku GY, Tan KS, Nussenzweig S, Wu A, Janjigian YY, Jones DR, Molena D. Safety and feasibility of esophagectomy following combined immunotherapy and chemoradiotherapy for esophageal cancer. The Journal of thoracic and cardiovascular surgery. 2021 Mar 1;161(3):836-43.
15. Fuchs HF, Collins JW, Babic B, DuCoin C, Meireles OR, Grimminger PP, Read M, Abbas A, Sallum R, Müller-Stich BP, Perez D. Robotic-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer training curriculum—a worldwide Delphi consensus study. Diseases of the Esophagus. 2022 Jun;35(6):doab055.
16. Xie CY, Pang CL, Chan B, Wong EY, Dou Q, Vardhanabhuti V. Machine learning and radiomics applications in esophageal cancers using non-invasive imaging methods—a critical review of literature. Cancers. 2021 May 19;13(10):2469.
17. Watanabe M, Toh Y, Ishihara R, Kono K, Matsubara H, Miyazaki T, Morita M, Murakami K, Muro K, Numasaki H, Oyama T. Comprehensive registry of esophageal cancer in Japan, 2015. Esophagus. 2023 Jan;20(1):1-28.
18. Casas MA, Angeramo CA, Harriott CB, Schlottmann F. Surgical outcomes after totally minimally invasive Ivor Lewis esophagectomy. A systematic review and meta-analysis. European Journal of Surgical Oncology. 2022 Mar 1;48(3):473-81.
19. Ali AM, Bachman KC, Worrell SG, Gray KE, Perry Y, Linden PA, Towe CW. Robotic minimally invasive esophagectomy provides superior surgical resection. Surgical Endoscopy. 2021 Nov;35:6329-34.
20. Zheng Y, Li Y, Liu X, Sun H, Shen S, Ba Y, Wang Z, Liu S, Xing W. Minimally invasive versus open McKeown for patients with esophageal cancer: a retrospective study. Annals of Surgical Oncology. 2021 Oct;28(11):6329-36.

Most read articles by the same author(s)