IMPACT OF THYROID AND GLYCEMIC STATUS IN PREMATURE HAIR GREYING
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Keywords
Premature hair greying, thyroid hormone, glycemic Status, oxidative stress, metabolic dysfunction, endocrine disturbances.
Abstract
Premature hair greying (PHG) is a dermatological condition characterized by the loss of hair pigment before the age of 25 years. While genetic predisposition plays a significant role, emerging evidence suggests that endocrine and metabolic disturbances, such as thyroid dysfunction and glycemic imbalances, may contribute to its pathogenesis. This study aimed to investigate the association between thyroid function (measured by TSH levels) and glycemic status (measured by RBS levels) in individuals with PHG compared to healthy controls. A Case control study was conducted involving 101 PHG subjects and 101 age- and gender-matched controls. Biochemical parameters, including TSH and RBS, were measured and compared between the groups. The results revealed significantly higher TSH levels (p < 0.0001) and elevated RBS levels (p < 0.0001) in the PHG group compared to controls. These findings suggest that thyroid dysfunction and altered glycemic status may play a significant role in the development of PHG, potentially through mechanisms involving oxidative stress. This study highlights the importance of screening for thyroid and glycemic abnormalities in individuals with PHG and provides a foundation for future research into the metabolic and endocrine pathways involved in premature greying.
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Pawan Joshi
PhD Scholar, Department of Biochemistry, National Institute of Medical Sciences and Research, Jaipur, Rajasthan
Sushma BJ
Professor and Head, Department of Biochemistry, National Institute of Medical Sciences and Research, Jaipur, Rajasthan
Sarajuddin Ansari
Assistant Professor, Department of Medicine, ASMC, Deoria, Uttar Pradesh