ROLE OF SERUM ZINC AND SERUM MAGNESIUM IN PROGNOSIS AND OUTCOME OF PATIENTS WITH TRAUMATIC BRAIN INJURY: A PROSPECTIVE STUDY
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Keywords
Traumatic Brain Injury, GCS, GOS, prognosis
Abstract
Traumatic brain injury has been considered as global public health issues. Almost 1.7 million people with isolated or multiple organ damage suffers from traumatic brain injury each year. Severe traumatic brain injury caused secondary multiple organ dysfunction and death. Serum Zinc and serum magnesium level in acute stages after traumatic brain injury (TBI) may be capable of predicting clinical and functional prognosis.
Materials and Methods This prospective study was carried out on 461 TBI patients sample who met the inclusion and exclusion criteria. Sample was collected from clinically diagnosed TBI patients within 24 hrs. Serum zinc and serum magnesium were determined on CST 180 in the central. The association of the serum zinc and serum magnesium determined with severity and outcome post treatment of the TBI patients by chi-square test.
Results: The serum zinc level was found normal range(65-118)µg/dl and serum magnesium level observed normal (1.6-2.4)mgldl except in the age group (51-60) where it was noticed reduced(1.23±0.39)mg/dl .The the association of serum zinc level (p=0.00001) and serum magnesium (p=0.00515) level with the outcome after six month(GOS based) were found significantly associated. Similarly, the association of severity (GCS Based) and Serum level of zinc (0.00001) and serum level of magnesium (0.0515) was also studied and observed significantly associated. Conclusion: The serum zinc level of zinc and serum level of magnesium were found both found significantly associated with both severity and outcomes of the TBI patients. The serum zinc and serum magnesium may play the role in prognosis of the diseases.
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Shyam Sundar Yadav
PhD Scholar, Department of Biochemistry, National Institute of Medical Sciences & Research, Nims University Rajasthan, Jaipur
Sushma BJ
Professor & HOD, Department of Biochemistry, National Institute of Medical Sciences & Research, Nims University Rajasthan, Jaipur
Sanjeev Attry
Professor, Department of Neurosurgery, National Institute of Medical Sciences & Research,
Nims University Rajasthan, Jaipur
Sumit Parashar
Tutor, Department of Biochemistry, National Institute of Medical Sciences & Research, Nims University Rajasthan, Jaipur