ASSOCIATION OF HYPERPROLACTINEMIA IN FEMALES WITH INFERTILITY
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Keywords
Hyperprolactinemia, infertility, prolactin, ovulation, thyroid dysfunction, hormonal imbalance, dopamine agonists
Abstract
Introduction: Hyperprolactinemia is an endocrine condition that interferes with ovulation, menstrual periods, and fertility and can affect women. High levels of prolactin inhibit the secretion of gonadotropin and disrupt estrogen levels, which affects the conception rate.
Objectives: The objective of this cross-sectional study is to test the relationship between hyperprolactinemia and infertility in women, report hormonal dysfunctions, and analyze factors affecting BMI and thyroid dysfunction in infertile women.
Materials and Methods: Cross sectional study was carried out at Khalifa Gul Nawaz Teaching Hospital Bannu, Pakistan and Khyber Teaching Hospital Peshawar, Pakistan. Selected subjects were 100 infertile women with hyperprolactinemia and 50 fertile women. It is based on the blood sampling of patients for the assessment of hormonal levels, BMI, thyroid profile, hormonal studied reproductive history etc. To determine the extent to which hyperprolactinemia was related to infertility, statistical tests were conducted.
Results: Infertile women had higher prolactin levels than normal levels (p < 0.001), a higher incidence of irregular menses (72%), and an incidence of subclinical hypothyroidism of 40%. TSH and BMI were also found to be higher than normal values of infertility.
Conclusion: Hyperprolactinemia is strongly associated with infertility, based on the disruption of the hormonal balance and metabolic disorders. Prevention, hormone therapy, and changing behavior are crucial to enhance the reproductive success of affected persons.
References
2- Dehghan, E., Namiranian, N., Ghadiri-Anari, A., Ratki, S.K.R. and Azizi, R., 2022. Evaluation of hyperprolactinemia risk factors in infertile women referred to Yazd Infertility Center: A cross-sectional study. International Journal of Reproductive BioMedicine, 19(12), p.1085.
3- Rai, S., Chhatar, S., Kalvit, S. and Kalvit, P., 2021. A Clinical Report on Association of Hypothyroidism and Hyperprolactinemia with Female Fertility. Acta Scientific CANCER BIOLOGY (ISSN: 2582-4473), 5(8).
4- Iancu, M.E., Albu, A.I. and Albu, D.N., 2023. Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature. Pharmaceuticals, 16(1), p.122..
5- Akhter, N., Khanday, A. and Mir, I.N., 2021. Hypothyroidism and Hyperprolactinemia as a Cause of Primary Infertility: A Single Center Study. International Journal of Infertility & Fetal Medicine, 12(3), pp.66-68.
6- Jain, U., Jain, D. and Jain, A., PATTERN OF CLINICAL PRESENTATION OF HYPERPLOLACTINEMIA AMONG INFERTILE PATIENTS. Headache, 1, pp.1-13.
7- Sharma, S., Meena, K., Tabiyad, A., Bhardwaj, M.K., Jaiswal, A. and Mehta, M., 2023. Correlation between prolactin, thyroid, LH, FSH, estradiol and progesterone in the infertile women. Int J Reprod Contracept Obstet Gynecol, 12(4), pp.1017-1022.
8- Kundu, S., Rao, S.S., Singh, K. and Rao, R., 2021. Study of thyroid profile and prolactin levels in female infertility patients: an institutional analysis. Journal of the Scientific Society, 48(1), pp.13-16.
9- Baker Badawei, A.A., ALakkad, A. and Murad, R., 2023. Correlation of hyperprolactinemia, Subclinical hypothyroidism with Polycystic Ovary Syndrome and infertility. Subclinical Hypothyroidism with Polycystic Ovary Syndrome and Infertility (March 15, 2023).
10- Elnour, A.A.A., Javed, M. and Elkhier, M.K.S., 2021. Comparison of prolactin, follicle-stimulating hormone, luteinizing hormone, estradiol, thyroid-stimulating hormone, free thyroxine and body mass index between infertile and fertile Saudi women. Obstetrics & Gynecology International Journal, 12(2), pp.119-122.
11- Hassan, A.A.M., Darwish, A.M., Ahmed, N.H. and Ali, R.R., 2022. Nurse's role in the management of hyperprolactinemia: a prospective randomized controlled trial. Assiut Scientific Nursing Journal, 10(28), pp.158-169.
12- Xu, X., Yang, A., Han, Y., Wang, W., Hao, G. and Cui, N., 2023. The association between serum prolactin levels and live birth rates in non-PCOS patients: A retrospective cohort study. Plos one, 18(11), p.e0295071.
13- Salimon, Y.A. and Olaniyan, M.F., 2024. Assessment of total and free testosterone, prolactin level among infertile women attending Gynecology Clinic in Ondo State. Sokoto Journal of Medical Laboratory Science, 9(2), pp.170-176.
14- Salma, U., Alanazi, M.F., Alshaikh, A.B.A., Alruwail, W.M.A., Alzamil, T.H.Z., Alruwaili, S.S.B., Alshalan, R.Z., Rewaily, B.H. and Rashwan, E.K., 2022. Risk Factors of Infertility in a Woman: A Case-Control Study. Malaysian Journal of Public Health Medicine, 22(2), pp.103-109.
15- Wojcik, M., Amer, S. and Jayaprakasan, K., 2022. The prevalence of hyperprolactinaemia in subfertile ovulatory women and its impact on fertility treatment outcome. Journal of Obstetrics and Gynaecology, 42(6), pp.2349-2353.
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Dr Saira Aslam
Consultant Gynae & Obs Department, Khalifa Gul Nawaz Teaching Hospital Bannu, Pakistan
Dr Mona Kanwal Naz
Associate Professor of Obstetrics & Gynaecology, Cantt General Hospital Rawalpindi, Pakistan
Dr Rahat Bibi
Resident Obs & Gynae, Department of Obstetrics & Gynaecolgy, Khyber Teaching Hospital Peshawar, Pakistan
Dr Amber Tasnim
Assistant Preofessor of Medicine, Abbottabad International Medical College, Pakistan
Dr Sara Umar
Department of Obs & Gynea, Fauji Foundation Hospital (Mailsi), Pakistan
Dr Surraya Israr
Associate Professor, Department of Obstericts & Gynaecology, GKMC /BKMC Swabi, Pakistan