Study the Relationship between FT3, FT4, and TSH with Some Bone Resorption Indexes in Hypothyroidism Men

Main Article Content

Asma'a H. Mohamed
Noor S. Naji
Ali H. Al-Saadi


Hypothyroidism, bone metabolism, bone mineral density


The current study was aimed to find the effect of hypothyroidism in men on metabolism and the density of some bone mineral. The study included patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as control group. the study comprised the estimation the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of lumbar spine and femoral neck. The results showed that In the hypothyroidism men group, 1. The bone mass was lower than the control group in significant differences . 2. The level of bone resorption index CTX-1 was significantly higher than that in control group; calcium and phosphorus were not differing from those in healthy control subjects. 3) TSH is positively correlated with CTX-1. male TSH and CTX-1 were positively correlated. Conclusions: There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.

Abstract 150 | pdf Downloads 74 PDF Downloads 97 XML Downloads 63 HTML Downloads 478


[1] Bassett JH, Williams GR. Role of Thyroid hormonesin Skeletal development and development [J]. Endocr Rev, 2016, 37(2): 135-187. DOI: 10.1210/er. 2015-1106.
[2] Baliram R, Latif R, Berkowitz J, et al. Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblast oogenesis in embryonic stem cell cultures[J]. ProcNatl A cad Sci USA, 2011, 108(39): 16277-16282. DOI: 10.1073/pnas. 1110286108.
[3] van Vliet NA, Nordam R, van Klinken JB, et al. Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two Sample Mendelian Randomization Study and a Candidate Gene Association Study[J]. J Bone Miner Res, 2018, 33(7): 1318-1325. DOI: 10. 1002/jbmr. 3426.
[4] Jin Yunyun, Ding Xuesuo. Correlation between hypothyroidism and bone mineral density in middle-aged and elderly women Correlation analysis [J]. Marker Immunoassay and Clinical, 2018, 25(4): 454-456, 486. DOI: 10.11748/bjmy. issn. 1006-1703. 2018.04.003.
[5] Waring AC, Harrison S, Fink HA, et al. A spective study of thyroid function, bone loss, and fractures in older men: The Mr OS study[J]. J Bone Miner Res, 2013, 28(3):472-479. DOI: 10.1002/jbmr.1774.
[6] Jamal SA, Leiter RE, Bayoumi AM, et al. Criticality Of laboratory testing in women with host eoporosis [J]. Osteoporos Int, 2005, 16(5): 534-540. DOI: 10.1007/ s00198-004-1718-y.
[7] Reid IR. Short-term and long-term effects of osteoporosis Therapies[J]. Nat Rev Endocrinol, 2015, 11(7): 418- 428. DOI: 10.1038/nrendo.2015.71.
[8] Vestergaard P, Mosekilde L. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide fol- low-upstudyin16, 249patients[J]. Thyroid, 2002, 12 (5): 411-419. DOI: 10.1089/105072502760043503
[9] Mohamed AH, ALKHAFAJI RS, Al-Saadi AH. Correlation between vitamin D deficiency and its receptor (FokI-rs2228570) gene polymorphisms in anemic men. Iran. J. Ichthyol. (Special issue 2022): 98-103.
[10] Segna D, Bauer DC, Feller M, et al. Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts[J]. J Intern Med, 2018, 283(1):56-72. DOI: 10.1111/joim.12688.
[11] Moon JH, Kim KM, Oh TJ, et al. The effect of TSH suppression on vertebral trabecular bones coresin patients With differentiated thyroid carcinoma [J]. J Clin Endocrinol Metab, 2017, 102(1): 78-85. DOI: 10.1210/jc. 2016-2740.
[12] Liao Eryuan. Endocrinology and Metabolism [M]. Beijing: People's Health Publishing House, 2012:1628-1706.
[13] Zaidi M, Davis TF, Zallone A, et al. Thyroid-stimulating hormone, thyroid hormones, and bone loss [J]. CurrOs-teoporos Rep, 2009, 7(2): 47-52.
[14] Busuttil BE, Frauman AG. TSH receiver expression Cardiac muscle tissue[J]. J Clin Endocrinol Metab, 2002, 87(6): 2994.
[15] Zaidan HK and Mohamed AH (2018) Neurotrophic factors determination of type II diabetic peripheral neuropathy patients. Biochem. Cell. Arch.,18( 2): 2051-2059.
[16] Stadlmayr W, Spitzweg C, Bichlmair AM, et al. TSH receptor transcripts and TSH receptor-like immune-reactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema [J].Thyroid, 1997, 7(1):3-12. DOI: 10.1089/thy. 1997.7.3.
[17] AbeE, Marians RC, YuW, et al. TSH is a negative regulator of skeletal remodeling [J]. Cell, 2003, 115(2):151-162. DOI: 10.1016/s0092-8674(03)00771-2.
[18] Boutin A, Neumann S, Gershengorn MC. Multitrans-division pathways mediate ethyrotropin receptor signaling In preosteoblast-like cells[J]. Endocrinology, 2016, 157(5): 2173-2181. DOI: 10.1210/en. 2015-2040.
[19] Neumann S, Eliseeva E, Boutique A, et al. Discovery of a Positive all osteric modulator of the rotropin receptor potentiation of thyrotropin-mediated pre osteoblast differentiation in vitro[J]. J Pharmacol Exp Ther, 2018, 364(1): 38-45. DOI: 10.1124/jpet. 117.244095.
[20] Hao Xiaoyun. Subclinical hypothyroidism and bone marrow in Taiyuan residents Metabolic correlation research [D]. Taiyuan:Shanxi Medical University, 2018.
[21] Zaidan HK, Mohammed AH. Glucagon like peptide-1 and C peptide level and their relationship with some physiological and biochemical variables of non-insulin dependent diabetes mellitus type 2 patient. Australian Journal of Basic and Applied Sciences. 2014 ; 8:1-10.
[22] Segna D, Bauer DC, Feller M, et al. Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts[J]. J Intern Med, 2018, 283(1):56-72. DOI: 10.1111/joim.12688.
[23] Liang Libo, Wang Youjuan, Zhang Mei, et al. subclinical hypothyroidism Correlation study with bone mineral density and bone metabolism indexes[J]. Sichuan University Chinese Journal of Medical Sciences, 2014, 45(1): 66-69, 83.
[24] Wang Jiadan, Zhang Qiao, Shi Lixin, et al. subclinical hypothyroidism Residents' serum 25-hydroxyvitamin D levels and cardiovascular risk factors Changes [J]. Chinese General Medicine, 2016, (22): 2671-2675. DOI: 10.3969/j. issn. 10079572.2016.22.012.
[25] Chinese Medical Association Osteoporosis and Bone Mineral Disease Branch. bone metabolism Guidelines for clinical application of chemical markers. Chinese osteoporosis and bone mineral Journal of Diseases, 2015, (4): 283-293. DOI: 10.3969/j. issn. 1674-2591.2015.04.001.
[26] Mosekilde L, Eriksen EF, Charles P. Effects of Hormones on bone and mineral metabolism[J]. Endocrinol Metab Clin North Am, 1990, 19(1): 35-63.
[27] Liu C, Zhang Y, Fu T, et al. Effects of magnetic Fields on bonne loss in hyperthyroidism rat model[J]. Bioelectronics, 2017, 38(2): 137-150. DOI: 10.1002/bem.22022.