INVESTIGATING THE ROLE OF VITAMIN D DEFICIENCY AND SUPPLEMENTATION IN ENHANCING FRACTURE HEALING RATES IN PATIENTS WITH LONG BONE FRACTURES
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Keywords
Vitamin D Deficiency, Fracture Healing, Long Bone Fractures
Abstract
Introduction: Nutrition and hormonal factors play a role in fracture healing, where vitamin D plays a major role in calcium and phosphate for bone repair. However, vitamin D deficiency hinders the fracture healing process. Supplementation appears effective, but best practices remain ill-defined.
Aim: The study aimed to evaluate the effects of vitamin D deficiency and supplementation for the fracture healing in patients with long bone fractures based on clinical and radiological parameters.
Methodology: Proposed quantitative study which would sample 200 patients, assigned into groups in accordance with their vitamin D levels – deficient, insufficient, and sufficient. Inadequate and poorly nourished groups got supplements. Clinical and radiographic assessments of the healing were done at 12 weeks. Statistical methods used for predictors included Kaplan-Meier and regression analyses.
Results: The results showed a significant difference in the healing time; the patient who had adequate vitamin D levels healed faster (p < 0.001). It has also been observed that where supplementation was taken, there were positive changes for both the deficient and insufficient groups but they were not on par with the sufficient group. The results have revealed that both the delayed union and nonunion rates were significantly higher in the deficient group as compared to the other groups. The functional outcome at the end of the follow up period was noted to be significantly higher in the sufficient group (Mean SMFA = 30.2 ; p < 0.001).
Conclusion: Inadequate levels of vitamin D prolong the process of bone fracture healing. Supplementation benefits the course of treatment but is most effective when base line nutrient levels are well attained. Daily monitoring for signs of depression, and necessary active engagement. More studies should then build upon these findings and streamline supplementation strategies while looking more closely at combination treatment schemes.
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Dr. Muhammad Shoaib Zardad
Assistant Professor, Ayub Medical College, Abbottabad, Pakistan
Dr. Muhammad Younas
Assistant Professor, Ayub Medical College, Abbottabad, Pakistan
Dr. Syed Usman Shah
Assistant Professor, Ayub Medical College, Abbottabad, Pakistan
Dr. Abid ur Rehman
Assistant Professor, Ayub Medical College, Abbottabad, Pakistan
Dr. Muhammad Ali Usman
Assistant Professor, Abbottabad International Medical Institute, Abbottabad, Pakistan
Dr. Baber Shahzad Sadiq
Consultant Orthopaedic Surgeon, Ayub Teaching Hospital, Abbottabad, Pakistan