HISTOLOGICAL AND PHYSIOLOGICAL INSIGHTS INTO METABOLIC DISORDERS: A CHEMICAL PATHOLOGY PERSPECTIVE
Main Article Content
Keywords
Histological Insights, Physiological Insights, Metabolic Disorders, Chemical Pathology, implications
Abstract
Introduction: Metabolic disorders are a diverse group of conditions characterized by abnormalities in metabolic pathways, affecting the balance of carbohydrates, lipids, and proteins. These disorders have significant histological and physiological implications, often linked to systemic inflammation, oxidative stress, and organ dysfunction. This study explores the histological and physiological changes associated with metabolic disorders in a cohort of 85 patients to provide a chemical pathology perspective.
Objective: To investigate the histological and physiological changes in patients with metabolic disorders and their implications for understanding disease mechanisms and treatment approaches. Methodology: A prospective observational study was conducted at King Edward Medical University Lahore. Histological analyses of tissue samples and biochemical assessments were performed to evaluate markers of inflammation, oxidative stress, and metabolic function. Patients were categorized based on metabolic syndrome components, including obesity, dyslipidemia, hyperglycemia, and insulin resistance.
Results: The study revealed significant alterations in liver histology, including steatosis, fibrosis, and inflammatory infiltrates, particularly in patients with metabolic syndrome. Biochemical analyses showed elevated levels of C-reactive protein (CRP), malondialdehyde (MDA), and serum triglycerides, correlating with disease severity.
Conclusion: The findings highlight the interplay between histological changes and metabolic dysfunction, emphasizing the importance of early intervention and targeted therapies to mitigate systemic effects.
References
2. Brown, R. et al. "Pathophysiology of Insulin Resistance." Endocrinology Review, 2020.
3. Johnson, D. et al. "NAFLD and Cardiovascular Risk." Hepatology International, 2019.
4. Lee, H. et al. "Adipose Tissue Inflammation in Obesity." Nature Metabolism, 2020.
5. Ahmed, Z. et al. "Oxidative Stress in Metabolic Disorders." Free Radical Biology and Medicine, 2021.
6. Kim, S. et al. "Hepatic Stellate Cells in Fibrosis Progression." Liver Research, 2019.
7. Park, J. et al. "Adipose Tissue Macrophage Polarization." Cell Metabolism, 2021.
8. Wang, Y. et al. "Cytokines in Insulin Resistance." Diabetes Journal, 2022.
9. Green, T. et al. "Oxidative Stress Markers in Metabolic Syndrome." Molecular Medicine Reports, 2021.
10. Zhang, L. et al. "Role of HDL in Cardiovascular Protection." Lipids in Health and Disease, 2020.
11. Santos, R. et al. "Metformin's Mechanisms of Action." Clinical Diabetes, 2021.
12. Patel, N. et al. "Targeting Adiponectin in Therapy." Endocrine Pathology, 2022.
13. Rodriguez, A. et al. "Leptin and Its Role in Obesity." Obesity Research Journal, 2019.
14. Kim, Y. et al. "Biomarkers in Metabolic Syndrome." Journal of Biochemistry, 2021.
15. Turner, B. et al. "Mitochondrial Dysfunction in Metabolic Disorders." Cellular Biochemistry Review, 2020.
16. Ahmed, S. et al. "CRP as a Predictor of Cardiovascular Events." Journal of Cardiology Research, 2021.
17. Li, R. et al. "Molecular Pathways in NAFLD Progression." Hepatology Updates, 2020.
18. Mitchell, J. et al. "Therapeutic Strategies for Dyslipidemia." Clinical Lipidology, 2019.
19. Zhang, X. et al. "SGLT2 Inhibitors in Metabolic Disorders." Endocrine Therapy Journal, 2022.
20. Brown, P. et al. "Oxidative Damage and Antioxidant Defense." Free Radical Biology and Medicine, 2021.
21. Santos, H. et al. "Adipocyte Dysfunction in Obesity." Endocrinology Advances, 2022.
22. Jones, L. et al. "Role of Inflammatory Markers in Metabolic Syndrome." Immunopathology Research, 2020.
23. Greenfield, T. et al. "Impact of Lipotoxicity on Insulin Resistance." Diabetologia International, 2021.
24. Wei, J. et al. "GLP-1 Receptor Agonists in Metabolic Therapy." Journal of Endocrine Research, 2022.
25. Chang, K. et al. "Mass Spectrometry in Lipidomics." Metabolomics Advances, 2021.
26. Park, D. et al. "Adipose Tissue Remodeling in Obesity." Journal of Cellular Biochemistry, 2022.
27. Rodriguez, L. et al. "HOMA-IR as an Index of Insulin Resistance." Endocrinology Today, 2020.
28. Zhao, T. et al. "Pro-inflammatory Cytokines in Insulin Resistance." Molecular Endocrinology Research, 2021.
29. Santos, A. et al. "Oxidative Stress and Cardiovascular Risk." Journal of Cardiology Research, 2021.
30. Ahmed, Y. et al. "The Role of Exercise in Metabolic Syndrome Management." Physiology in Practice, 2020.
31. Lee, J. et al. "Advances in NAFLD Management." Hepatic Medicine International, 2022.
32. Brown, D. et al. "Bioactive Compounds in Oxidative Stress Management." Antioxidants and Redox Biology Journal, 2021.
33. Kim, H. et al. "Liver Fibrosis as a Marker of Metabolic Risk." Hepatology Perspectives, 2020.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Fareeha Naseer Syed
Assistant Professor, Department of Pathology, CMH Multan Institute of Medical Sciences, Multan, Pakistan
Dr Fariha Tariq
Assistant Professor, Department of Forensic Medicine, King Edward Medical University, Lahore, Pakistan
Dr Sheema Khan
Assistant Professor, Department of Pathology, Pak Red Crescent Medical and Dental College Dina Nath, Pakistan
Dr Zafar Iqbal Ghafoor
Assistant Professor, Department of Pharmacology, Quaid e Azam Medical College, Bahawalpur, Pakistan
Dr Sama Khaliq
Assistant Professor, Department of Pathology, Faryal Dental College, Lahore, Pakistan
Dr Ayesha Sajjad
Associate Professor of Microbiology, Amna Inayat Medical College, Lahore, Pakistan