FREQUENCY OF PULMONARY HYPERTENSION IN PATIENTS WITH INTERSTITIAL LUNG DISEASE

Main Article Content

Shahid Zia
Yasir Ahmed
Saadia Ashraf
Muhammad Fayaz

Keywords

Pulmonary hypertension, interstitial lung disease, echocardiography, prevalence, age, clinical outcomes.

Abstract

Objectives: The aim of this study is to find out the prevalence of pulmonary hypertension (HP)  in patients with interstitial lung disease (ILD) and the relationship between the frequency of PH and age, gender, smoking history, and disease duration.


Materials and Methods: The current with a cross-sectional descriptive design was carried out in KTH, Peshawar, from September 28, 2019, to March 27, 2020. Patients with ILD who volunteered for the study were recruited after an explanation of the study procedures, risks, and benefits by the investigators to the patients or their surrogates. Echocardiography of the right side of the heart was done using transthoracic echocardiography (TTE) which was used to thereby determine the degree of pulmonary hypertension. Using SPSS version 16, students’ demographic details and illness experiences were categorized, and numerical data was compared.


Results: Out of 95 patients 27 patients (28.42 percent) were diagnosed to have PH. PH was more common in the elderly, where 42.9% of samples from patients over 60 years of age had PH. PH was not significantly correlated to gender, smoking history, or disease duration.


Conclusion: PH is common in ILD patients, particularly those of older age. Regular screening tests are helpful in the early detection of diseases such that they can be managed to improve a patient’s health status.


 

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References

1- Parikh, R., Konstantinidis, I., O'Sullivan, D.M. and Farber, H.W., 2022. Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection. Pulmonary Circulation, 12(4), p.e12141.
2- Rahaghi, F.F., Kolaitis, N.A., Adegunsoye, A., de Andrade, J.A., Flaherty, K.R., Lancaster, L.H., Lee, J.S., Levine, D.J., Preston, I.R., Safdar, Z. and Saggar, R., 2022. Screening strategies for pulmonary hypertension in patients with interstitial lung disease: a multidisciplinary Delphi study. Chest, 162(1), pp.145-155.
3- Alhamad, E.H., Cal, J.G., Alrajhi, N.N. and Alharbi, W.M., 2020. Predictors of mortality in patients with interstitial lung disease-associated pulmonary hypertension. Journal of Clinical Medicine, 9(12), p.3828.
4- Shlobin, O.A., Adir, Y., Barbera, J.A., Cottin, V., Harari, S., Jutant, E.M., Pepke-Zaba, J., Ghofrani, H.A. and Channick, R., 2024. Pulmonary hypertension associated with lung diseases. European Respiratory Journal, 64(4).
5- Guillén-Del-Castillo, A., Meseguer, M.L., Fonollosa-Pla, V., Giménez, B.S., Colunga-Argüelles, D., Revilla-López, E., Rubio-Rivas, M., Ropero, M.J.C., Argibay, A., Barberá, J.A. and Salas, X.P., 2022. Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension. Scientific reports, 12(1), p.5289.
6- Nikkho, S.M., Richter, M.J., Shen, E., Abman, S.H., Antoniou, K., Chung, J., Fernandes, P., Hassoun, P., Lazarus, H.M., Olschewski, H. and Piccari, L., 2022. Clinical significance of pulmonary hypertension in interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's innovative drug development initiative—Group 3 pulmonary hypertension. Pulmonary Circulation, 12(3), p.e12127.
7- Waxman, A.B., Elia, D., Adir, Y., Humbert, M. and Harari, S., 2022. Recent advances in the management of pulmonary hypertension with interstitial lung disease. European Respiratory Review, 31(165).
8- Chauvelot, L., Gamondes, D., Berthiller, J., Nieves, A., Renard, S., Catella‐Chatron, J., Ahmad, K., Bertoletti, L., Camara, B., Gomez, E. and Launay, D., 2021. Hemodynamic response to treatment and outcomes in pulmonary hypertension associated with interstitial lung disease versus pulmonary arterial hypertension in systemic sclerosis: data from a study identifying prognostic factors in pulmonary hypertension associated with interstitial lung disease. Arthritis & Rheumatology, 73(2), pp.295-304.
9- Sangani, R.A., Lui, J.K., Gillmeyer, K.R., Trojanowski, M.A., Bujor, A.M., LaValley, M.P. and Klings, E.S., 2022. Clinical characteristics and outcomes in pulmonary manifestations of systemic sclerosis: Contribution from pulmonary hypertension and interstitial lung disease severity. Pulmonary Circulation, 12(4), p.e12117.
10- Nathan, S.D., Waxman, A., Rajagopal, S., Case, A., Johri, S., DuBrock, H., De La Zerda, D.J., Sahay, S., King, C., Melendres-Groves, L. and Smith, P., 2021. Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study. The Lancet Respiratory Medicine, 9(11), pp.1266-1274.
11- Lee, J.H., Park, C.S. and Song, J.W., 2020. Obstructive sleep apnea in patients with interstitial lung disease: prevalence and predictive factors. PLoS One, 15(10), p.e0239963.
12- Alhamad, E.H. and Cal, J.G., 2020. Predictors of mortality in interstitial lung disease patients without pulmonary hypertension. Annals of Thoracic Medicine, 15(4), pp.238-243.
13- Montani, D., Cifrián, J.M., Rojo, R.P., Nunes, H., Meloni, F., Ghio, S., Cannon, J., Günther, A., García, H.G., Delgado, M.F. and Jeanneret, G.S.B., 2024. Unmet need in pulmonary hypertension-associated interstitial lung disease (PH-ILD): a clinician survey of real-world management of PH-ILD in Europe. ERJ Open Research, 10(4).
14- Nathan, S.D., Tapson, V.F., Elwing, J., Rischard, F., Mehta, J., Shapiro, S., Shen, E., Deng, C., Smith, P. and Waxman, A., 2022. Efficacy of inhaled treprostinil on multiple disease progression events in patients with pulmonary hypertension due to parenchymal lung disease in the INCREASE trial. American journal of respiratory and critical care medicine, 205(2), pp.198-207.
15- Hyldgaard, C., Bendstrup, E., Pedersen, A.B., Pedersen, L. and Ellingsen, T., 2021. Interstitial lung disease in connective tissue diseases: survival patterns in a population-based cohort. Journal of Clinical Medicine, 10(21), p.4830.

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