PAROXYSMAL SUPRA-VENTRICULAR TACHYCARDIA: FACTORS DETERMINING ADENOSINE SENSITIVE VS ADENOSINE RESISTANCE

Abstract

Objective

To analyze the demographic features, medical history and clinical features which may or may not be responsible for adenosine resistance among patients of supra-ventricular tachycardia presenting to the cardiac emergency department.

Methodology

A single centered, prospective, cross-sectional, comparative study conducted from May 14 to August 15, 2022 on 100 patients with supra-ventricular tachycardia presenting to emergency department of Sheikh Zayed Medical College/Hospital were included in the study after fulfilling inclusion criteria.

Results

Mean age was 41.32 years with 38% patients being males and 62% being females. Total 71% patients reported to be adenosine sensitive and 29% patients were adenosine resistant. 71% presented with palpitations, 17% with palpitations and shortness of breath both and 10% with palpations and chest pain, 2% with shortness of breath alone. No significant co-relation was observed between demographic characteristics (age, gender, BMI, clinical presentation) and adenosine resistance. Moreover, in adenosine resistant group of 29 patients, 10 had history of SVT, 17 had diabetes mellitus, 23 had hypertension, 11 had history of IHD/HF, 5 had history of anti-psychotic medications, 18 had history of asthma/COPD, 2 had history of thyroid disorder, 19 had history of smoking, 15 had history of caffeine intake, 3 had history of alcohol intake, 7 had history of cola intake.

Conclusion                                                   

It is concluded that adenosine resistance in patients of paroxysmal supra-ventricular tachycardia is independent of demographic characteristics but, some factors including hypertension, Asthma/COPD, smoking and caffeine/alcohol/cola intake do play some role in the adenosine resistance, as effect modifiers.