DEVELOPEMENT AND IN VIVO EVALUATION OF GASTRO RETENTIVE FLOATING MICROBALLOONS OF PIRENTANIDE
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Keywords
Eudragit S 100, Eudragit RS 100, Ethyl Cellulose, Floating Microballons, Hydroxy Propyl Methyl Cellulose (HPMC), Piretanide.
Abstract
The present investigation deals with the development and evaluation of floating microballoons of Piretanide to extend the gastric residence time (GRT) and prolong the drug release. In the present work, floating microballoons of Piretanide were formulated using Eudragit RS 100, Eudragit S 100, and HPMC K4M and ethyl cellulose polymers by the solvent evaporation method. The prepared microballoons were evaluated for their physicochemical properties, in-vitro drug release, and in-vitro buoyancy. The in-vivo Radiographic study showed that the barium sulphate loaded optimized formulation remained buoyant up to 5.5 h in the stomach. The in-vivo pharmacokinetic study was conducted in healthy albino rabbits revealed that the oral bioavailability of optimized formulation was increased significantly when compared to the marketed formulations. The increased bioavailability may be due to the floating mechanism of the dosage form in the stomach for longer duration.
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Matsyagiri Lenkalapally
Department of Pharmaceutics, Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally (V), Yadagirigutta (M), Yadadri- Bhongiri (D), 508286, Telangana, India.
Dr. Mangulal Kethavath
Brilliant School of Pharmacy, Abdullapurmet, Rangareddy-Dist, Telangana, India