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Daniel S. Sitar


Aging, drug disposition, CSCP Senior Investigator Award


Dr. Dan Sitar was the recipient of the 2004 CSCP Senior Investigator Award at the First Canadian Therapeutics Congress held in June 2004. He presented a lecture highlighting some of the studies he participated in that have contributed to an increased understanding of the role of aging on drug disposition and effect.


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1. Aoki FY, Hildahl VK, Large GR, Mitenko PA, Sitar DS. Aging and heavy drug use: a prescription survey in Manitoba. J Chronic Dis 1983;36:75-84.
2. Grymonpre RE, Mitenko PA, Sitar DS, Aoki FY, Montgomery PR. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988;36:1092-8.
3. Sitar DS, Hunninghake DB. Pharmacokinetics of propylthiouracil in man after a single oral dose. J Clin Endocrinol Metab 1975;40:26-9.4.
4. Sitar DS, Abu-Bakare A, Gardiner RJ. Propylthiouracil disposition in older hypothyroid patients. Pharmacology 1988;36:121-4
5. Sitar DS, Piafsky KM, Rangno RE, Ogilvie RI. Plasma theophylline concentrations measured by high pressure liquid chromatography. Clin Chem
6. Montgomery PR, Aoki FY, Mitenko PA, Vanzieleghem M, Sitar DS. Slow release theophylline disposition and effect in elderly patients with chronic obstructive lung disease: influence of dose formulation and institutionalization. Biopharm Drug Disposit 1989;10:481-8.
7. Wilson A, Sitar DS, Molloy WD, McCarthy D. The effect of age and chronic obstructive pulmonary disease on the Breathalyzer estimation of blood alcohol level. Alcoholism Clin Exp Res 1987;11:440-3.
8. Owen JA, Sitar DS. Morphine analysis by high performance liquid chromatography. J Chromatogr 1983;276:202-7.
9. Owen JA, Sitar DS, Berger L, Brownell L, Duke, PC Mitenko PA. Age-related morphine kinetics. Clin Pharmacol Ther 1983;34:364-8.
10. Sitar DS, Duke PC, Benthuysen JL, Sanford TJ, Smith NT. Aging and alfentanil disposition in healthy volunteers and surgical patients. Can J Anaesth
11. Ariano RE, Duke PC, Sitar DS. Population pharmacokinetics of fentanyl in healthy volunteers. J Clin Pharmacol 2001;41:757-63.
12. Bras APM, Janne J, Porter CW, Sitar DS. Spermidine/spermine N1-acetyltransferase catalyzes amantadine acetylation. Drug Metab Disposit 2001;29:676-80.
13. Aoki FY, Sitar DS. Amantadine kinetics in healthy elderly men: implications for influenza prevention. Clin Pharmacol Ther 1985;37:137-44.
14. Aoki FY, Sitar DS. Clinical pharmacokinetics of amantadine hydrochloride. Clin Pharmacokinet 1988;14:35-51.
15. Kolbe F, Sitar DS, Papaioannou A, Campbell G. An amantadine dosing program adjusted for renal function during an influenza outbreak in elderly institutionalized
patients. Can J Clin Pharmacol 2003;10:119-22.
16. Gaudry SE, Sitar DS, Smyth DD, McKenzie JK Aoki FY. Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther 1993;54:23-7.