EFFECT OF CHICORY ROOT POWDER ON TOTAL CHOLESTROL AND BLOOD PRESSURE OF THE HYPERTENSIVE PATIENTS

Main Article Content

Mehak Sajid
Dr. Niamat Ullah
Azim Khan
Hikmat Ullah Khan
Aqsa Noureen
Bakhtawar

Keywords

Chicory root powder, Total Cholesterol, Blood Pressure, Hypertensive patient

Abstract

Background: Cichorium intybus belongs to family Asteraceae, is an enriched source of inulin, a fructan-type plant polysaccharide, whose ability has been shown to have a significant effect on total cholesterol and blood pressure in numerous studies with controversial results.


Aims and Objectives: The aim of the present study was to explore the effect of chicory root powder on total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and blood pressure of the hypertensive patients.


Study Design: It was controlled randomized clinical trial.


Methodology: A total of 30 hypertensive patients both male and female age ≥ 40 years were enrolled in this study. The patients were randomly divided into three groups, where each group was comprised with 10 hypertensive patients. The first group was Control group (n=10) who received only hot water, the second group (group 2) received 5 gm of chicory root powder (n=10) and third group (group 3) received 10 gm of chicory root powder (n=10). All the participants were assessed at day 0 (baseline), day 15, day 30 followed by wash out period at day 45.


Statistical Analysis: Statistical package for social sciences (SPSS) Version 21 was used to analyze the data.


Results: The result of this study revealed that after the supplementation for the thirty days a significant difference at the entire interval for all the different treatment was recorded. Significant (p<0.05) declined in blood pressure and total cholesterol, LDL and increase in HDL in treatment group was observed. There was significant difference (p<0.05) in blood pressure and total cholesterol, LDL and HDL values between the Control and treatment groups. Finding of this study shown that 10 gm dose of Chicory root powder for 30 days was effective in reducing the total cholesterol and blood pressure of hypertensive patient with hypercholesterolemia. it was concluded that chicory root powder can be used for controlling the blood pressure and total cholesterol of hypertensive patient.

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References

1. Abbas, Z. K., Saggu, S., Sakeran, M. I., Zidan, N., Rehman, H., and Ansari, A. A. 2015. Phytochemical, antioxidant and mineral composition of hydroalcoholic extract of chicory (Cichorium intybus L.) leaves. Saudi J. Biol. Sci. 22(3): 322-326
2. Abdel-Rahim, E. A., Rashed, M. M., El-Hawary, Z. M., Abdelkader, M. M., Kassem, S. S. & Mohamed, R. S. 2016. Anti-diabetic effect of cichorium intybus leaves and plantago ovate seeds in high fat diet-streptozotocin induced diabetic rats. J. Food Nutr. Res., 4, 276-281.
3. Ahmed, L. A., Ramadan, R. S., and Mohamed, R. A. 2009. Biochemical and histopathological studies on the water extracts of marjoram and chicory herbs and their mixture in obese rats. Pak J. Nutr. 8(10):1581-1587
4. Ahmed, N. 2009. Alloxan diabetes-induced oxidative stress and impairment of oxidative defense system in rat brain: neuroprotective effects of cichorium intybus. Int J. Diabetes Metab. 17: 105-109
5. Aksoy, A. 2008. Chicory (Cichorium intybus L.): a possible biomonitor of metal pollution. Pak. J. Bot. 40(2): 791-797
6. Al-Snafi, A. E. 2016. Medical importance of Cichorium intybus–A review. IOSR Journal of Pharmacy. 6(3): 41-56
7. Antza, C., Stabouli, S., and Kotsis, V. 2018. Gut microbiota in kidney disease and hypertension. Pharmacological research. 130: 198-203
8. Babaei, H., Forouzandeh, F., Maghsoumi-Norouzabad, L., Yousefimanesh, H. A., Ravanbakhsh, M. & Zare Javid, A. 2018. Effects of chicory leaf extract on serum oxidative stress markers, lipid profile and periodontal status in patients with chronic periodontitis. Journal of the American College of Nutrition, 37, 479-486.
9. Becerril-Alarcón, Y., Campos-Gómez, S., Valdez-Andrade, J. J., Campos-Gómez, K. A., Reyes-Barretero, D. Y., Benitez-Arciniega, A. D., Valdés-Ramos, R. & Soto-Piña, A. E. 2019. Inulin supplementation reduces systolic blood pressure in women with breast cancer undergoing neoadjuvant chemotherapy. Cardiovascular Therapeutics, 2019.
10. Bishnoi, S., 2016. Herbs as functional foods. book: Functional Food: Sources and Health Benefits, pp.141-165.
11. Emery, E. E., Woodhead, E. L., Molinari, V. & Hunt, M. G. 2010. Treatment adherence in late-life. Handbook of Assessment in Clinical Gerontology, 427-457.
12. Faghihimani, Z., Namazi, N., Ghaffari, S., Rezaei Kelishadi, M., Sharifi, S., Nattagh Eshtivani, E., Roshanravan, N. 2021. Effects of Inulin Type-Carbohydrates on blood pressure: a systematic review and meta-analysis. International Journal of Food Properties. 24(1): 129-139
13. Ghaffari, A., Rafraf, M., Navekar, R., Sepehri, B., Asghari-Jafarabadi, M. & Ghavami, S.-M. 2019. Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD). International Journal for Vitamin Nutrition Research.
14. Golzarand, M., Bahadoran, Z., Mirmiran, P., & Azizi, F. (2022). Inulin intake and the incidence of cardiometabolic diseases: a prospective cohort study. Food Function, 13(20), 10516-10524.
15. Hsu, C.N., Hou, C.Y., Lee, C.T., Chang-Chien, G.P., Lin, S., and Tain, Y.L. 2021. Maternal 3, 3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure. Nutrients. 13(9): 3041
16. Hsu, C.N., Lin, Y.J., Hou, C.Y., and Tain, Y.L. 2018. Maternal administration of probiotic or prebiotic prevents male adult rat offspring against developmental programming of hypertension induced by high fructose consumption in pregnancy and lactation. Nutrients. 10(9): 1229
17. Jurgoński, A., Milala, J., Juśkiewicz, J., Zduńczyk, Z., & Król, B. (2011). Composition of chicory root, peel, seed and leaf ethanol extracts and biological properties of their non-inulin fractions. Food Technology Biotechnology, 49(1), 40-47.
18. Juśkiewicz, J., Zduńczyk, Z., Żary-Sikorska, E., Król, B., Milala, J., & Jurgoński, A. (2011). Effect of the dietary polyphenolic fraction of chicory root, peel, seed and leaf extracts on caecal fermentation and blood parameters in rats fed diets containing prebiotic fructans. British Journal of Nutrition, 105(5), 710-720.
19. Kim, M. 2000. The water-soluble extract of chicory reduces cholesterol uptake in gut-perfused rats. Nutrition Research. 20(7): 1017-1026
20. Kim, M., and Shin, H. K. 1996. The water-soluble extract of chicory reduces glucose uptake from the perfused jejunum in rats. The Journal of nutrition. 126(9): 2236-2242
21. Lairon, D. 1996. Nutritional and metabolic aspects of postprandial lipemia. Reproduction Nutrition Development. 36(4): 345-355
22. Lepczyński, A., Herosimczyk, A., Barszcz, M., Ożgo, M., Michałek, K., Grabowska, M., . . . Skomiał, J. (2021). Diet supplemented either with dried chicory root or chicory inulin significantly influence kidney and liver mineral content and antioxidative capacity in growing pigs. Animal, 15(2), 100129.
23. Liew, S. J., Lee, J. T., Tan, C. S., Koh, C. H. G., Van Dam, R. & Müller-Riemenschneider, F. 2019. Sociodemographic factors in relation to hypertension prevalence, awareness, treatment and control in a multi-ethnic Asian population: a cross-sectional study. BMJ open, 9, e025869.
24. Mazaheri, M., Babaeian, M., Ekhveh, M., Vakili, Z., and Vakili, Z. 2022. Efficacy of herbal tea preparation including mallow flower, chicory seeds, sweet violet, Melilotus officinalis, and bindii for improving respiratory symptoms in patients with COVID-19; a randomized controlled clinical trial
25. Moradi, S. M., Javidan, A., & Isfahani, H. N. (2013). Effects of probiotic ultra-filtered feta cheese and raw chicory root extract on lipid profile in healthy adult volunteers: a triple-blinded randomized controlled trial. Mediterranean Journal of Nutrition Metabolism, 6(3), 199-206.
26. Mulabagal, V., H. Wang, M. Ngouaiio and M.G. Nair. 2009. Characterization and quantification of health beneficial anthocyanins in leaf chicory (Cichorium intybus) varieties. European Food Research and Technology, 230(1), 47-53
27. Nagao, M., Nakajima, H., Toh, R., Hirata, K.-i. & Ishida, T. 2018. Cardioprotective effects of high-density lipoprotein beyond its anti-atherogenic action. Journal of Atherosclerosis Thrombosis, RV17025.
28. Nasimi Doost Azgomi, R., Karimi, A., Tutunchi, H., and Moini Jazani, A. 2021. A comprehensive mechanistic and therapeutic insight into the effect of chicory (Cichorium intybus) supplementation in diabetes mellitus: A systematic review of literature. International Journal of Clinical Practice. 75(12): 14945
29. Nasiri, A., Ziamajidi, N., Behrouj, H., Abbasalipourkabir, R. & Dehghan, A. 2014. The effects of aqueous extract of chicory root on steatosis, lipid profile and liver damage enzyme markers in tamoxifen-treated rats. Molecular Biochemical Diagnosis Journal, 1, 185-194.
30. Nishimura, M., Ohkawara, T., Kanayama, T., Kitagawa, K., Nishimura, H. & Nishihira, J. 2015. Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties. Journal of Traditional Complementary Medicine, 5, 161-167.
31. Nwafor, C.I., K.Shale and C. Achilonu. 2017.Chemical composition and nutritive benefits of chicory (Cichorium intybus) as an ideal complementary and/or alternative livestock feed supplement. The Scientific World Journal.
32. Paswan, V.R., H. Rose, C.S. Singh, S. Yamini and A. Rathaur. 2021. Herbs and Spices Fortified Functional Dairy Products. In Herbs and Spices-New Processing Technologies.IntechOpen
33. Pauly, M. J., Rohde, J. K., John, C., Evangelakos, I., Koop, A. C., Pertzborn, P., Worthmann, A. 2020. Inulin supplementation disturbs hepatic cholesterol and bile acid metabolism independent from housing temperature. Nutrients. 12(10): 3200
34. Payab, M., Kelishadi, R., Qorbani, M., Motlagh, M. E., Ranjbar, S. H., Ardalan, G., Zahedi, H., Chinian, M., Asayesh, H. & Larijani, B. 2015. Association of junk food consumption with high blood pressure and obesity in Iranian children and adolescents: the CASPIAN-IV Study. Jornal de Pediatria, 91, 196-205.
35. Perovic, J., Saponjac, V. T., Kojic, J., Krulj, J., Moreno, D. A., García-Viguera, C., Ilic, N. 2021. Chicory (Cichorium intybus L.) as a food ingredient–Nutritional composition, bioactivity, safety, and health claims: A review. Food chemistry. 336: 127676
36. Rifat-uz-Zaman, M., and Khan, M. S. 2006. In vitro antibacterial screening of Anethum graveolens L. fruit, Cichorium intybus L. leaf, Plantago ovata L. seed husk and Polygonum viviparum L. root extracts against Helicobacter pylori. Int J Pharmacol. 2: 674-677
37. Saggu, S., Sakeran, M. I., Zidan, N., Tousson, E., Mohan, A., and Rehman, H. 2014. Ameliorating effect of chicory (Chichorium intybus L.) fruit extract against 4-tert-octylphenol induced liver injury and oxidative stress in male rats. Food and chemical toxicology. 72: 138-146
38. Sedighi, M., Cheraghi, M., Faghihi, M., Asghar Kiani, A., Dehghani, M., Rasoulian, B. & Nazari, A. 2021. Hypotensive effect of Cichorium intybus extract in rats. Journal of Herbmed Pharmacology.
39. Society, B. C., Society, B. H., Diabetes, U., Society, P. C. C., and Association, S. 2005. JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart (British Cardiac Society). 91(Suppl 5): 1-52
40. Sidana, J., Street, R. A., and Prinsloo, G. 2013. Cichorium intybus: Traditional uses, phytochemistry, pharmacology, and toxicology. Evidence-Based Complementary and Alternative Medicine. 2013
41. Street, R. A., Sidana, J., & Prinsloo, G. (2013). Cichorium intybus: Traditional uses, phytochemistry, pharmacology, and toxicology. Evidence-Based Complementary and Alternative Medicine, 2013.
42. Wilson, R. G., Smith, J. A. & Yonts, C. D. 2004. Chicory root yield and carbohydrate composition is influenced by cultivar selection, planting, and harvest date. Crop Science, 44, 748-752.
43. Winnicki, M., Somers, V. K., Dorigatti, F., Longo, D., Santonastaso, M., Mos, L., Mattarei, M., Pessina, A. C., Palatini, P. & Group, H. S. 2006. Lifestyle, family history and progression of hypertension. Journal of Hypertension, 24, 1479-1487.
44. Wu, Y., Zhou, F., Jiang, H., Wang, Z., Hua, C. & Zhang, Y. 2018. Chicory (Cichorium intybus L.) polysaccharides attenuate high-fat diet induced non-alcoholic fatty liver disease via AMPK activation. International Journal of Biological Macromolecules, 118, 886-895.
45. Yang, J., Zhang, S., Henning, S. M., Lee, R., Hsu, M., Grojean, E., Li, Z. 2017. Effects of Dietary Pomegranate Extract and Inulin in Mice Fed an Obesogenic Diet. The FASEB Journal. 31: 646.657-646.657