PULMONARY FUNCTION, ANTIOXIDANT ENZYMES, AND MELATONIN LEVELS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE DURING STABLE AND EXACERBATION PERIODS

Abstract

Background: In the development and progression of bronchial asthma and chronic obstructive pulmonary disease important role is played by an imbalance between oxidative stress and antioxidative capacity. The purpose of the study was to evaluate the BA and COPD systemic oxidant-antioxidant status during the exacerbation and the stable periods.

Methodology: This study was conducted at DHQ Hospital, Charsadda. ‘The patients with BA and COPD’ were 40, which were divided into 20 with BA and 20 with COPD. An investigation was carried out i-e “levels of malondialdehyde (MDA), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GRd), and catalase (CAT) in erythrocytes and serum melatonin concentrations” ‘during the exacerbation’ and the stable periods. Additionally, the respiratory functions, blood gases, and Blood counts were investigated.

Results: Bronchial asthma during an exacerbation period the % of eosinophils was higher significantly than in the stable period despite the declines in, GRd, GSH-Px, MDA, melatonin levels, white blood cell count, and CAT levels. We evaluate that increased during the stable period with, FVC/L, BA FEV¹/L pO², PEF/L/s, levels. GSH-Px, GRd, melatonin, pH, and pO² levels were lower in the exacerbation period than in the stable period while MDA and SOD values were higher in the exacerbation period than in the stable period. The change between the exacerbation and the stable period with COPD, blood counts, and respiratory function tests did not change significantly.

Conclusion: (BA or COPD) may be linked with elevated levels of oxidative stress, because of increased levels of oxidative stress in the exacerbation period with BA and COPD although the levels decreased antioxidant enzymes and melatonin.