EARLY POSTPARTUM LIPID PROFILE IN WOMEN WITH AND WITHOUT GESTATIONAL DIABETES MELLITUS: RESULTS OF A PROSPECTIVE COHORT STUDY
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Keywords
Gestational Diabetes Mellitus, Postpartum, Dyslipidaemia
Abstract
Background: During pregnancy Gestational diabetes mellitus (GDM) a type of sugar disorder is typically first identified. It affects mothers globally. According to the International Diabetes Federation 14% of pregnancies are impacted by GDM leading to approximately 18 million babies being born with this condition each year.
Objective: To compare the lipid profiles of women with and without gestational diabetes mellitus at early postpartum.
Methodology: A prospective cohort study design was chosen for this investigation in order to compare the lipid profiles of women with and without gestational diabetes mellitus (GDM) in the early postpartum phase. This study was conducted in Mardan Medical Complex from time span of January 2022 to December 2022. Lipid parameters were measured by collecting fasting blood samples from all participants at 8 weeks after childbirth. The lipid parameters consisted of total cholesterol levels, cholesterol carried by low-density lipoprotein (LDL-C), cholesterol in high-density lipoprotein (HDL-C), TG stands for triglycerides. Blood samples underwent analysis using standardized laboratory procedures.
Results: Eight weeks after giving birth, lipid measurements were assessed. In comparison to the non-GDM group, the GDM group showed noticeably higher levels of triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC). There was no discernible difference in the two groups' levels of HDL-C, or high-density lipoprotein cholesterol.
Conclusion: The results of this study highlight the clear impact of GDM on lipid metabolism in the early postnatal period. TC followed by LDL-C and TG were higher in women with previously diagnosed metabolic syndrome of GDM, which is a strong indicator of CV disease risk. These outcomes support postpartum care programs, educational efforts, and lifestyle changes to help prevent future health outcomes associated with GDM. Monitoring and identifying these risk factors can change women with GDM prolonged cardiovascular health thereby reducing the burden of cardiovascular diseases in this vulnerable group.
References
2. Alejandro EU, Mamerto TP, Chung G, Villavieja A, Gaus NL, Morgan E, Pineda-Cortel MR. Gestational diabetes mellitus: a harbinger of the vicious cycle of diabetes. International journal of molecular sciences. 2020 Jul 15;21(14):5003.
3. Amiri FN, Faramarzi M, Bakhtiari A, Omidvar S. Risk factors for gestational diabetes mellitus: a case-control study. American journal of lifestyle medicine. 2021 Mar;15(2):184-90.
4. Chen YH, Chen WY, Chang CY, Cho CY, Tang YH, Yeh CC, Yang YH, Tsao PC, Lee YS. Association between maternal factors and fetal macrosomia in full-term singleton births. Journal of the Chinese Medical Association. 2023 Mar 1;86(3):324-9.
5. Smith GN, Louis JM, Saade GR. Pregnancy and the postpartum period as an opportunity for cardiovascular risk identification and management. Obstetrics & Gynecology. 2019 Oct 1;134(4):851-62.
6. Hu J, Gillies CL, Lin S, Stewart ZA, Melford SE, Abrams KR, Baker PN, Khunti K, Tan BK. Association of maternal lipid profile and gestational diabetes mellitus: A systematic review and meta-analysis of 292 studies and 97,880 women. EClinicalMedicine. 2021 Apr 1;34.
7. Herrera E, Desoye G. Maternal and fetal lipid metabolism under normal and gestational diabetic conditions. Hormone molecular biology and clinical investigation. 2016 May 1;26(2):109-27.
8. Thongtang N, Sukmawan R, Llanes EJ, Lee ZV. Dyslipidemia management for primary prevention of cardiovascular events: Best in-clinic practices. Preventive medicine reports. 2022 Jun 1;27:101819.
9. Liu XY, Wu QY, Chen ZH, Yan GY, Lu Y, Dai HJ, Li Y, Yang PT, Yuan H. Elevated triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio increased risk of hyperuricemia: a 4-year cohort study in China. Endocrine. 2020 Apr;68:71-80.
10. Parikh NI, Gonzalez JM, Anderson CA, Judd SE, Rexrode KM, Hlatky MA, Gunderson EP, Stuart JJ, Vaidya D, American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and the Stroke Council. Adverse pregnancy outcomes and cardiovascular disease risk: unique opportunities for cardiovascular disease prevention in women: a scientific statement from the American Heart Association. Circulation. 2021 May 4;143(18):e902-16.
11. Khoury, J. C., Snyder, G. G., Habash, M., et al. (2022). Postpartum dyslipidemia in women with and without gestational diabetes mellitus: A prospective cohort study. Journal of Clinical Endocrinology & Metabolism, 107(2), 481-489.
12. Xie, W., Wang, Y., Li, Z., et al. (2020). Lipid profiles and the risk of developing gestational diabetes mellitus in pregnant women: A retrospective cohort study. BMC Pregnancy and Childbirth, 20(1), 46.
13. Pei L, Xiao H, Lai F, Li Z, Li Z, Yue S, Chen H, Li Y, Cao X. Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus. Lipids in Health and Disease. 2020 Dec;19:1-8.
14. Lee, Y. N., Choi, S. H., Park, M. H., et al. (2021). Postpartum metabolic profiles in women with previous gestational diabetes mellitus. Diabetes & Metabolism Journal, 45(4), 509-517.
15. Wang, S., Zhou, Y., Zhang, Y., et al. (2023). Changes in lipid profiles and associations with insulin resistance in postpartum women with a history of gestational diabetes mellitus. Journal of Diabetes Research, 2023, Article ID 2936012.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Kalsum Khan
MBBS, MRCPI Obstetrics and Gynaecology, MRCOG Part 2, UK, Registrar Obs and Gynae, Letterkenny University Hospital, Ireland
Dr Reema Gul
Junior Registrar, Department Obstetrics and Gynecology, Mardan Medical Complex/MTI, Mardan, Pakistan
Dr Gul Muhammad
Assistant Professor, Department of Physiology, Rehman Medical College, Peshawar, Pakistan
Dr Salman Khan
Associate Professor, Department of Medicine, DHQ Teaching Hospital/Gomal Medical College, Dera Ismail Khan, Pakistan
Dr Umair Wadood
Assistant Professor, Department of Physiology, Rehman College of Dentistry, Peshawar, Pakistan
Dr Shafiq Alam
Assistant Professor, Department of Cardiology, Bacha Khan Medical College/ MTI, Mardan, Pakistan