SAFETY PROFILE AND TOXICOLOGICAL EVALUATION OF ESSENTIAL OILS OF CURCUMA LONGA AND SYZYGIUM AROMATICUM
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Keywords
Essential oil, Curcuma longa, Syzygium aromaticum, MTT Assay, AMES test, Comet Assay
Abstract
Medicinal plants are the major source of natural organic compounds and are universally used as alternative medicines. Essential oils of Curcuma longa (turmeric) and Syzygium aromaticum (Clove) have anti-inflammatory, antioxidant, analgesic, anti-rheumatic, and antimicrobial properties. However, if essential oils of these plants have to be used as therapeutic agents, then their safety and toxicity also need to be addressed. In the present study, the safety profile of essential oils of Syzygium aromaticum and Curcuma longa were evaluated by Comet assay, MTT assay, and AMES test. Both essential oils exhibited good tolerability and safety profiles at a concentration of 50 µL/mL that was quite higher than the MICs observed against different multidrug-resistant pathogenic bacteria. The IC-50 values observed were 58 and 62.79 for Syzygium aromaticum and Curcuma longa respectively. It was concluded that the essential oils of Syzygium aromaticum and Curcuma longa have a good safety profile and can be used for medicinal purposes.
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Muhammad Qamar Zeshan
Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore
Muhammad Ashraf
Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore
Muhammad Ovais Omer
Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore
Aftab Ahmad Anjum
Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore
Muhammad Asad Ali
Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore
Muhammad Mubashar Beig
Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore
Shagufta Yasmin
Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan
Javeria Majeed
Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore