NEUROGENESIS EFFECT OF TIANEPTINE VS VORTIOXETINE
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Keywords
Tianeptine, vortioxetin, Depression, anxiolytic, antidepressan
Abstract
Background: Depression, a debilitating psychiatric disorder, is characterized by enduring feelings of sadness and a diminished capacity to derive pleasure or interest from everyday activities. While the exact causes and comprehensive comprehension of the neurochemical processes that contribute to mood disorders are not fully understood, there is already significant evidence connecting mood problems to other conditions such as heart disease, osteoporosis, diabetes mellitus, and cerebral ischemia.
Aim: This study aims to assess the neurogenesis effect of tianeptine vs vortioxetine
Method: Eighty white albino male rats (200-225 g) were used. Induction of depression by reserpine, then determine the brain serotonin content in each group of rats and evaluate the antidepressant and antioxidant parameters for tianeptine and vortioxetine treated groups.
Results: Tianeptine exhibited superior outcomes compared to vortioxetine in the majority of assessments.
Conclusion: The findings obtained from the study indicate that the use of tianeptine exhibits superior antidepressant effects than vortioxetinein in the treatment of depressive disorder because it has an antidepressant effect that might be mediated in rats through neuroprotective effect evident as antioxidant activity and restoration of brain weight.
References
2. Allain, F., Ehrlich, A. T., McNicholas, M., Gross, F., Ma, W., Kieffer, B. L., & Darcq, E. (2022). Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice. Frontiers in Psychiatry, 14, 1186397.
3. Antkiewicz-Michaluk L, Wąsik A, Możdżeń E, Romańska I, Michaluk J. (2014). Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat. Neurotox Res.;26(1):85-98.
4. Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., da Cruz Almeida, W. L., Rescia, V. C., ... & Oesterreich, S. A. (2019). Molecular aspects of depression: a review from neurobiology to treatment. European Journal of Pharmacology, 851, 99-121.
5. Bogdanski, D.F., Pletscer, A., Brodie, B.B. and Friend, S. (1956): Identification and assay of serotonin in brain. J. Pharmac. Exp. Ther. , 117: 82-88.
6. Cuijpers, P., Stringaris, A., & Wolpert, M. (2020). Treatment outcomes for depression: challenges and opportunities. The Lancet Psychiatry, 7(11), 925-927.
7. Dudas, R., Malouf, R., McCleery, J., Dening, T. (2018) Antidepressants for treating depression in dementia. Cochrane Database Syst Rev 8, CD003944
8. Halaris, A., Emilie Sohl and Elizabeth A. Whitham (2021) Treatment-Resistant Depression Revisited: A Glimmer of Hope. J. Pers. Med. 2021, 11, 155.
9. Han, J., Andreu, V., Langreck, C., Pekarskaya, E. A., Grinnell, S. G., Allain, F., & Nautiyal, K. M. (2022). Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. Neuropsychopharmacology, 47(7), 1387-1397.
10. Hao ZY, Zhong Y, Ma ZJ, Xu HZ, Kong JY, Wu Z et al.(2020).Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder. BMC Psychiatry ; 20(1): 71.
11. Inoue, T., Shinji Fujimoto, Tatsuro Marumoto, Tadayuki Kitagawa, Kazuyuki Ishida, Tadashi Nakajima, Yoshiya Moriguchi, Keita Fujikawa, Koichiro Watanabe (2021). Therapeutic Potential of Vortioxetine for Anxious Depression: A Post Hoc Analysis of Data from a Clinical Trial Conducted in Japan. Neuropsychiatric Disease and Treatment, vol. 17, 3781-379.
12. Javier De Diego-Adeliño, José Manuel Crespo, Fernando Mora, Adrián Neyrad , Pedro Iborra, Luis GutiérrezRojas and Selman F. Saloniag (2022): Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review. EXPERT OPINION ON DRUG SAFETY 2022, VOL. 21, NO. 5, 673–690.
13. Li, Z., Ruan, M., Chen, J., & Fang, Y. (2021). Major depressive disorder: advances in neuroscience research and translational applications. Neuroscience Bulletin, 37, 863-880.
14. Lopez-Castroman, J., Jaussent, I., Gorwood, P., & Courtet, P. (2020). Activation syndrome induced by the antidepressant tianeptine and suicidal ideation: Evidence from a large depressed outpatient sample. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 97, 109762.
15. Mar, J., ´ ´ıa Garc´ıa-Alberca∗, Esther Gris, Paz de la Gu´ıa and Silvia Mendoza (2022). Effects of Tianeptine Treatment on Depression and Cognitive Function in Patients with Alzheimer’s Disease: A 12-Month Retrospective Observational Study. Journal of Alzheimer’s Disease 88 (2022) 707–720.
16. McIntyre, R. S. , Mohammad Alsuwaidan, Bernhard T. Baune, Michael Berk, Koen Demyttenaere, Joseph F. Goldberg, Philip Gorwood, Roger Ho, et al., (2022). Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions World Psychiatry; 22:394–412
17. Paget, G.E. and Barnes, J.M. (1964). Toxicity tests. Chapter 6.
18. Pekarskaya, E. A., Holt, E. S., Gingrich, J. A., Ansorge, M. S., Javitch, J. A., & Canetta, S. E. (2021). Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine. Scientific Reports, 11(1), 22852.
19. Perić, I., Andrijana Stanisavljević , Dragos Inta, Peter Gass, Undine, E., Lang , Stefan Borgwardt , Dragana Filipović. (2019). Tianeptine antagonizes the reduction of PV+ and GAD67 cells number in dorsal hippocampus of socially isolated rats. Prog. Neuro-Psychopharmacology Biol. Psychiatry 89, 386–399.
20. Perić, I., Costina, V., Findeisen, P., Gass, P., & Filipović, D. (2020). Tianeptine enhances energy-related processes in the hippocampal non-synaptic mitochondria in a rat model of depression. Neuroscience, 451, 111-125.
21. Puryear, C.B., Brooks, J., Tan, L., Smith, K., Li, Y., Cunningham, J., et al. (2020). Opioid receptor modulation of neural circuits in depression: what can be learned from preclinical data? Neurosci Biobehav Rev.;108:658–78.
22. Runia, N., Yücel, D. E., Lok, A., de Jong, K., Denys, D. A., van Wingen, G. A., & Bergfeld, I. O. (2022). The neurobiology of treatment-resistant depression: a systematic review of neuroimaging studies. Neuroscience & Biobehavioral Reviews, 132, 433-448.
23. Sajjadian, M., Lam, R. W., Milev, R., Rotzinger, S., Frey, B. N., Soares, C. N., ... & Uher, R. (2021). Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis. Psychological Medicine, 51(16), 2742-2751.
24. Spellman, T., & Liston, C. (2020). Toward circuit mechanisms of pathophysiology in depression. American Journal of Psychiatry, 177(5), 381-390.
25. ZAVVARI, F., NAHAVANDI, A. & SHAHBAZI, A., 2020. Neuroprotective effects of cerium oxide nanoparticles on experimental stress-induced depression in male rats. J. Chem. Neuroanat. 106, 101799.
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Sahar Badr El-Din
Department of Pharmacology, Faculty of Medicine For Girls, Al-Azhar University Cairo Egypt.
Ramadan Hassan Ibrahim Thabet
Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Sherif M. A. Mansour
Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Eman Wahsh
Department of Pharmacology & Toxicology, Faculty of Pharmacy, Sinai university, Arish branch.
Ahmed El-Sayed Nour El-Deen
Department of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ahmed Gad Allah
Department of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Muhammad Abdelbaeth Hassan Elfiky
Department of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Mohamed R. Elnady
Department of Physiology, Faculty of Medicine, Al-Azhar university, Damietta, Egypt
Ahmed Mohmed Gad Allah
Department of Forensic medicine and clinical Toxicology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Heba K. Badawy
Department of Biochemistry, Faculty of Pharmacy, Sinai University, Arish Branch, North Sinai, Egypt.
Abd El-salam Ahmed
Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.