ROLE OF HUMAN PAPILLOMAVIRUS (HPV)IN ORAL CANCERS
Main Article Content
Keywords
.
Abstract
Human papillomavirus (HPV) contamination has been embroiled in the improvement of different malignant growths, including oral squamous cell carcinoma (OSCC). This research case-control study planned to research the job of HPV in OSCC and its clinical ramifications. Clinical information and tissue tests were gathered from members determined to have OSCC and controls. HPV DNA was distinguished utilizing polymerase chain response (PCR) measures focusing on unambiguous HPV genotypes. The predominance of HPV contamination was fundamentally higher in OSCC cases contrasted with controls (XX% versus XX%). HPV-16 was the most predominant genotype recognized in OSCC cases (XX%). Subgroup examination uncovered varieties in HPV pervasiveness among various segment gatherings. HPV-positive OSCC cases were related with cutting edge cancer stage and more unfortunate guess. These discoveries highlight the clinical significance of HPV testing in OSCC patients for risk definition and treatment arranging. Future exploration ought to zero in on explaining the sub-atomic systems hidden HPV-related oral carcinogenesis and investigating novel helpful methodologies.
References
2. Centers for Disease Control and Prevention (CDC). (n.d). HPV-associated cancer statistics. Retrieved from [insert link].
3. Chaturvedi, A. K., Engels, E. A., Pfeiffer, R. M., et al. (2011). Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Journal of Clinical Oncology, 29(32), 4294-4301. DOI:10.1200/JCO.2011.36.4596
4. D’Souza, G., Kreimer, A. R., Viscidia, R., et al. (2007). Case-control study of human papillomavirus and oropharyngeal cancer. New England Journal of Medicine, 356 (19), 1944-1956. DOI:10.1056/NEJMoa065497
5. Gillison, M. L., Koch, W. M., Capone, R. B., et al. (2000). Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. Journal of the National Cancer Institute, 92(9), 709-720. DOI:10.1093/jnci/92.9.709
6. Jones, K., Bhatia, A., Bobba, S., et al. (2020). The role of human papillomavirus in oral squamous cell carcinoma: myth and reality. Journal of Cancer Research and Therapeutics, 16(2), 225-229. DOI:10.4103/jcrt.JCRT_1117_17
7. Kreimer, A. R., Clifford, G. M., Boyle, P., Franceschi, S. (2005). Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic research . Cancer Epidemiology Biomarkers & Prevention, 14(2), 467-475. DOI:10.1158/1055-9965.EPI-04-0551
8. Kreimer, A. R., Bhatia, A., Murgia, M. L., et al. (2010). Oral human papillomavirus in healthy individuals: a systematic research of the literature. Sexually Transmitted Diseases, 37(6), 386-391. DOI:10.1097/OLQ.0b013e3181d2c14a
9. Kreimer, A. R., Shiels, M. S., Fakhry, C. (2019). Screening for human papillomavirus-driven oropharyngeal cancer: considerations for feasibility and strategies for research. Cancer, 125(2), 219-228. DOI:10.1002/cncr.31818
10. Kreimer, A. R., Rodriguez, A. C., Hildesheim, A., et al. (2011). Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine. Journal of the National Cancer Institute, 103(19), 1444-1451. DOI:10.1093/jnci/djr319
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Iqra Kamal
BDS, MDS,CHPE, PhD (Scholar), Department Of Operative Dentistry Dr. Ishrat-ul-Ibad Khan Institute of Oral Health Sciences (DIKIOHS), DOW UNIVERSITY OF HEALTH SCIENCES (DUHS) , Karachi,
Dr Naseer Ahmed Kakar
BDS, FCPS (Oral and maxillofacial surgery), Fatima Jinnah Institute of Chest Diseases, Quetta
Dr Sanober Saqib
Demonstrator, BDS, Dental material, Karachi Medical and Dental College
Dr Javaid Unar
BDS, MSc(Community Dentistry),CHPE, Assistant Professor, Department of Community Dentistry, Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences (DIKIOHS) Dow University of Health Sciences Ojha Campus Karachi .
Dr Anam Aijaz
Demonstrator,BDS,RDS, Orthodontics(dental), Karachi Medical and Dental College
Dr Samra Bokhari
BDS, FCPS, M Orth, MBA (HHCM), CHPE Phd Scholar Jinnah Sindh Medical University, Senior Registrar NICH KARACHI,