COMPARISON OF ORAL ISOTRETINOIN VS ISOTRETINOIN WITH VITAMIN D3 (CHOLECALCIFEROL) IN THE TREATMENT OF ACNE VULGARIS

Abstract

Objective:

To check the effect of oral Isotretinoin vs Isotretinoin with Vitamin D3 (Cholecalciferol) in the treatment of Acne Vulgaris

Material and Methods:

This prospective cohort study was conducted in the outpatient dermatology clinic at Sandeman Provincial Hospital. Before initiating the study, a written informed consent was received from the participants after explaining the aim, value, and necessary steps in a simplified manner and the potential side effects of isotretinoin drugs.

Results:

Acne vulgaris remains a prevalent dermatological concern, impacting individuals of all ages and genders worldwide, necessitating effective treatment modalities to address its multifactorial nature. This article presents a comparative analysis of treatment outcomes between oral isotretinoin monotherapy and a combination regimen comprising oral isotretinoin and vitamin D supplementation. Our findings illuminate the superior efficacy of the combination therapy, with the group receiving isotretinoin alongside vitamin D demonstrating marked improvement in clinical results. Drawing from a robust cohort study involving acne patients, we meticulously assess and contrast the efficacy of these treatment modalities. Our findings unveil a notable disparity in treatment response, with the group receiving combination therapy exhibiting significantly greater improvement in clinical outcomes compared to those undergoing isotretinoin monotherapy. Through this exploration, we advocate for a holistic approach to acne treatment, emphasizing the potential benefits of adjunctive vitamin D supplementation in enhancing therapeutic outcomes. This study provides valuable insights to optimize treatment strategies and improve patient care in the management of acne vulgaris.

Conclusion:
In conclusion, combining oral isotretinoin with vitamin D supplementation demonstrates superior efficacy in treating acne vulgaris compared to isotretinoin monotherapy. The study underscores the importance of holistic approaches to acne management and highlights the potential benefits of adjunctive vitamin D therapy optimizing therapeutic outcomes for patients.