PHARMACEUTICAL FORMULATION STRATEGIES FOR ENHANCING DRUG BIOAVAILABILITY AND THERAPEUTIC EFFICACY
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Keywords
pharmaceutical formulation, bioavailability, therapeutic efficacy, drug development, drug delivery
Abstract
In the field of pharmaceuticals, enhancing drug bioavailability and therapeutic efficacy is crucial in ensuring the success of a drug formulation. Various formulation strategies have been developed to improve the absorption, distribution, metabolism, and excretion of drugs in the body. This essay explores some of the key strategies utilized in pharmaceutical formulation for enhancing drug bioavailability and therapeutic efficacy. The methods used to achieve these, the results obtained from these approaches, and the implications for drug development are discussed. Finally, the essay concludes with a summary of the importance of these strategies in the pharmaceutical industry.
References
2. Pooja D., Mitra, A. K., & Talegaonkar, S. (2008). Nanoparticles: potential carriers for delivery of therapeutics in retinal diseases. Journal of Controlled Release, 126(1), 2-13.
3. Bodratti, A. M., & Alexandridis, P. (2018). Formulation of polyelectrolyte complexes, biopolymer-based microcapsules, and surfaces using the layer-by-layer method. Chemical Society Reviews, 47(18), 7629-7651.
4. Drug delivery systems: Advanced technologies potentially applicable in personalized treatments. (2021). Applied Materials Today, 23, 101040.
1. 5 Dahan,., Miller, J. M., & Amidon,. E. (2010). Prediction of solubility and permeability class members of drug compounds using artificial neural networks. Journal of medicinal chemistry, 53(16), 5858-5867.
5. Chen, M. L., & Shah, V. (2011). Patents on oral controlled release drug delivery technology over the past one decade–a quantifiable perspective. Drug discovery today, 16(3), 105-112.
6. Pouton, C. W. (2006). Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. European journal of pharmaceutical sciences, 29(3-4), 278-287.
7. Haesdonck, C., Laub, A., & Spiegel M. R. (2015). Ethyl cellulose microcapsules for antioxidant delivery to food. Food research international, 68, 349-355.
8. Child, J. & Wyatt, A. (2017). Approach to Improve High Drug Potency: Development of Amorphous Solid Dispersion for an Insoluble. Current Drug Delivery, 13(6), 861-868.
9. Li, J., Shah V. & Bao Z. (2019). Strategies that Improve Solubility, Dissolution and Absorption of Poorly Water-Soluble Drugs. Drug Delivery, 26(1), 288-307.
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Abdallah Marey Aboshhran
Technician Pharmacy, King Fahd General hospital Jeddah
Yasser Mesfer alqhtani
Technician pharmacy, King Fahad General hospital jeddah
Mohammed Hammad Nafel Aljohany
Technician pharmacy, King Fahad General Hospital Jeddah
Alaa Hameed alsolami
Pharmacist technician, King Fahad General Hospital Jeddah
Abdullaziz Edan Aldafiry
Pharmacist technician, Managing commitment to Riyadh Health