PUBLIC INTEREST IN THE OFF-LABEL USE OF GLUCAGON-LIKE PEPTIDE 1 AGONISTS (OZEMPIC) FOR COSMETIC WEIGHT LOSS‏

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Abdallah Marey Aboshhran
Saeed Ali Alqahtani
Yasser Mesfer Alqhtani
Ahmed Saleh Alharthi
Abdulrahman Hussain Fawwaz Kahl
Khaled Mohsin Ismail Khormi

Keywords

GLP-1 agonists, Ozempic, off-label use, weight loss, public interest

Abstract

The off-label use of Glucagon-like Peptide 1 (GLP-1) agonists, such as Ozempic, for cosmetic weight loss has garnered significant public interest in recent years. This essay explores the implications of this trend on public health, ethical considerations, and regulatory frameworks. The introduction provides a background on GLP-1 agonists and their approved medical uses, while the methods section outlines the various sources consulted to gather information for this essay. The results section highlights the benefits and risks associated with off-label use of GLP-1 agonists for weight loss. The discussion section delves into the ethical considerations surrounding this practice, including potential risks and benefits, while the conclusions summarize the main points raised in the essay. Finally, the reference list provides a comprehensive list of reputable sources consulted for this essay.

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References

1. Astrup A, Rössner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet. 2009;374(9701):1606-1616. doi:10.1016/s0140-6736(09)61375-1
2. Wadden TA, Hollander P, Klein S, et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Int J Obes (Lond). 2013;37(11):1443-1451. doi:10.1038/ijo.2013.120
3. Liraglutide for Weight Loss NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK285521/. Accessed September 13, 2021.
4. Blonde L, Russell-Jones D. The safety and efficacy of liraglutide, a glucagon-like peptide-1 agonist, in the treatment of type 2 diabetes. Expert Opin Drug Saf. 2009;8(2):129-135. doi:10.1517/14740330803469265
5. Lau J, Bloch P, Schaffer L, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015;58(18):7370-7380. doi: 10.1021/acs.jmedchem.5b00726
6. Tivi S. Semaglutide - the Quest for the Holy Grail of Weight Loss. Pharm J. February 2021:2021.
7. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344. doi:10.1136/bmj.d7771
8. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans. Diabetes. 2001;50(8):1714-1719. doi:10.2337/diabetes.50..1714
9. Knudsen LB. Glucagon-Like Peptide-1 Agonists for the Treatment of Type 2 Diabetes: Differences and Similarities. Eur J Intern Med. 2014;25(5):407-414. doi:10.1016/j.ejim.2014.03.006
10. Frías JP, Davies MJ, Rosenstock J, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021;385(6):503-515. doi:10.1056/NEJMoa2107519

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