CORRELATING URIC ACID LEVELS WITH HYPERTENSION: INSIGHTS FROM A TERTIARY CARE HOSPITAL

Main Article Content

Nadia Siddiqui
Sandhiya Kumari
Komal Devi
Anjlee Sawlani
Marryam Choudhary
Sandya Bai

Keywords

Hypertension, Hyperuricemia, Uric acid

Abstract

Aim/Objective: To determine the frequency of hyperuricemia (high levels of uric acid) among those who have been diagnosed with hypertension.


Materials and Methods: A cross-sectional descriptive study was carried out at Liaquat National Hospital and Medical College Karachi, Pakistan in the duration from September, 2023 to February, 2024, enrolling 100 patients diagnosed with primary hypertension. Serum uric acid levels were analyzed to identify hyperuricemia, defined as levels exceeding >7.0 mg/dL for males and >6.5 mg/dL for females. The results suggested a hyperuricemia occurrence of 62%, with no significant age-related differences observed. Notably, males exhibited a higher incidence of hyperuricemia.


Results: The study included 100 patients, with 53% men and 47% women. The patients' average age was 52.03 ± 08.27 years, with a mean blood uric acid level of 6.85 ± 0.74 mg/dl. A gender-specific investigation indicated an important distinction in hyperuricemia frequencies between both genders, with 40% of male and 22% of females having high uric acid levels. Age-based comparison, however, showed no significant disparity in hyperuricemia prevalence between age groups.


Conclusion: This study elucidates the link between a high level of uric acid(UA) and hypertension, emphasizing the significance of constant uric acid level surveillance in hypertensive patients. These insights facilitate targeted interventions for effective cardiovascular risk management in clinical practice.

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References

1. Ansari RN, Gandhi RV, Saiyed M, Jain KD. Study of prevalence and impact of hyperuricemia in a patient of hypertension. Int J Adv Med. 2017;4(2):367.
2. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The lancet. 2012;380(9859):2224-60.
3. Raja S, Kumar A, Aahooja RD, Thakuria U, Ochani S, Shaukat F. Frequency of hyperuricemia and its risk factors in the adult population. Cureus 2019; 11(3): e4198
4. Aziz K, Faruki M, Manolio T, Davis CE Abernathy J. Blood pressure and hypertension distribution in lower middle class urban society in Pakistan. J Pak Med Assoc 2005; 55(8): 333-38.
5. Zhang X, Meng Q, Feng J, Liao H. The prevalence of hyperuricemia and its correlates in ganzi tibetan auto-nomous prefecture, sichuan Province, China. Lipids Health Dis 2018; 17(1): 235
6. Jin M, Yang F, Yang I, Yin Y, Luo JJ, Wang H, et al. Uric acid, hyperuricemia and vascular diseases. Frontiers in bioscience: a journal and virtual library. 2012;17:656.
7. Muszyński P, Dąbrowski EJ, Pasławska M, Niwińska M, Kurasz A, Święczkowski M, et al., editors. Hyperuricemia as a risk factor in hypertension among patients with very high cardiovascular risk. Healthcare; 2023: MDPI.
8. Bilal MH, Tahir M. Frequency of hyperuricemia in hypertensive patients presenting at DG Khan Hospital, DG Khan. Pak J Med Health Sci. 2015;9(2):547-49.
9. Sharma P, Singh P, Bhinda A. Hyperuricemia: a systemic review. World J Pharm Res. 2021;10(01):911-22.
10. Stewart DJ, Langlois V, Noone D. Hyperuricemia and hypertension: links and risks. Integrated blood pressure control. 2019:43-62.
11. Chen Y-Y, Kao T-W, Yang H-F, Chou C-W, Wu C-J, Lai C-H, et al. The association of uric acid with the risk of metabolic syndrome, arterialhypertension or diabetes in young subjects-an observational study. Clinica Chimica Acta. 2018;478:68-73.
12. Anand N, Padma V, Prasad A, Alam KC, Javid MSM. Serum uric acid in new and recent onset primary hypertension. Journal of Pharmacy & Bioallied Sciences. 2015;7(Suppl 1):S4.
13. Kanellis J, Kang D-H, editors. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Seminars in nephrology; 2005: Elsevier.
14. El Din UAS, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: a review. Journal of advanced research. 2017;8(5):537-48.
15. Shaikh AA, Altaf A. Prevalence of hyperuricemia in Sukkur; Pakistan: A cross sectional survey. The Professional Medical Journal. 2019;26(09):1567-9.
16. Afifi A, Sarhan I, El Sharkawy M, Kamel M, Anwar W, Helmy N, et al. Uric acid metabolism in a sample of Egyptian hypertensive patients with normal kidney function. The Egyptian Journal of Hospital Medicine. 2013;52(1):608-14.
17. Rehman A, Sattar A, Abaidullah S, Hasan M. Evaluation of Cardiovascular Risk Factors in Patients with Essential Hypertension. Annals of King Edward Medical University. 1999;5(2):134-7.
18. Dasti D, Hashmi DA, Shah D, Hussain D, Gohar D, Farah D, et al. Essential hypertension; hyperuricemia in patients. Professional Med J Q 2015; 22(12): 1555-59.
19. Taniguchi Y, Hayashi T, Tsumura K, Endo G, Fujii S, Okada K. Serum uric acid and the risk for hypertension men: The Osaka Health Survey. J Hypertens 2001; 19(7): 1209-15