Hydrazone Ligand and Metal Complexes: A Comprehensive Study on Synthesis, Characterization, and Urease Inhibition Potential
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Abstract
This investigation delved into the imine group of hydrazones, elucidating its role in biological systems and emphasizing bioactivity and stable metal complexes vital for coordination chemistry. The main goal was to synthesize a hydrazone ligand, specifically 2-hydroxybenzaldehyde-N-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene), abbreviated as AG-41, along with its associated metal complexes utilizing Co(II), Ni(II), Cu(II), and Zn(II) ions.Top of Form
The newly synthesized compounds underwent comprehensive characterization, with a focus on revealing their structures and evaluating urease inhibition activity. The research aimed to identify novel metal complexes, employing hydrazone as ligands, which were synthesized and thoroughly characterized using various analytical techniques, including FT-IR, EI-mass, elemental analysis, UV-Visible, magnetic susceptibility, and conductivity studies. It was observed that in all cases, the ligand AG-41 exhibited tridentate coordination with the metal center. The ultimate goal was to contribute to understanding the structural determinants influencing urease inhibition, laying the groundwork for innovative urease inhibitors with potential applications in medical and industrial domains. Results indicated that the metal complexes showed moderate potency, they were less effective in comparison to the hydrazone ligand. Importantly, both the ligand AG-41 and its precursor AG-40 displayed outstanding inhibitory properties when compared to the standard molecule i.e. Thiourea.
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